| Company Name: |
Meryer (Shanghai) Chemical Technology Co., Ltd.
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| Tel: |
4006608290; 18621169109 |
| Email: |
market03@meryer.com |
| Products Intro: |
Product Name:trans-2-Carboxy-5,7-dichloro-4-phenylaMinocarbonyl aMino-1,2,3,4-tetrahydroquinoline
CAS:139051-78-8
Remarks:AAM128239
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:L-689,560;trans-2-Carboxy-5,7-dichloro-4-phenylaMinocarbonylaMino-1,2,3,4-tetrahydroquinoline
CAS:139051-78-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | L-689,560 Basic information |
| Product Name: | L-689,560 | | Synonyms: | L-689,560;TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE;4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline;2-Quinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-, (2R,4S)-rel- | | CAS: | 139051-78-8 | | MF: | C17H15Cl2N3O3 | | MW: | 380.23 | | EINECS: | | | Product Categories: | | | Mol File: | 139051-78-8.mol |  |
| | L-689,560 Chemical Properties |
| Melting point | 172-173°C | | Boiling point | 549.1±50.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | <9.51mg/ml in DMSO; <38.02mg/ml in ethanol | | form | solid | | pka | 11.16±0.20(Predicted) | | color | White |
| | L-689,560 Usage And Synthesis |
| Uses | L-689,560 is a potent antagonist at the glycine-NMDA receptor site. | | Definition | ChEBI: 4-[[anilino(oxo)methyl]amino]-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid is a member of quinolines. | | Biological Activity | Very potent antagonist at the glycine-NMDA site. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ . | | in vitro | l-689560 is described as one of the most potent nmda antagonists and [4'-3h]-l-689560 has been thought to be a highly specific radioligand for the glycine site. in consistent with the 5,7-disubstituted kynurenates, the tetrahydroquinolines are selective antagonists of glycine site nmda, l-689560 exhibiting at least 3 orders of magnitude selectivity versus the glutamate site [1]. | | in vivo | mdl100748 with an ed50 of 83 mg kg-1 can prevent audiogenic seizures in susceptible mice after systemic injection. as a standard l689560, its subsequent analogues have been compared; the displacement of [3h] l689560 has often been used to displace that of [3h] glycine as an alternative assay. l701252, a quinones (the retention of a keto grouping at position 3), has been against l689560 binding (ic50 of 420 nm) and against seizures (ed50 of 4.1 mg kg-1) in dba/2 mice. a group of sulfonamide analogues of kynurenic acid are also in active among the 2-quinolone series. those of a series of 3,4-dihydroquinolones and tetrahydroquinolines with a nitrosubstituent at 3-position were selective antagonists at the nmda receptor glycine site if they bore a bulky grouping in the position 4. the compound with no substitution at position 4 was proved to be one of the most effective broad-spectrum antagonists against nmda and ampa receptors [2]. | | storage | Store at RT | | references | [1]. leeson pd, carling rw, moore kw, moseley am, smith jd, stevenson g, chan t, baker r, foster ac, grimwood s, et al. 4-amido-2-carboxytetrahydroquinolines. structure-activity relationships for antagonism at the glycine site of the nmda receptor. j med chem. 1992 may 29;35 (11): 1954-68.
[2]. stone tw. development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. trends pharmacol sci. 2000 apr; 21(4):149-54. |
| | L-689,560 Preparation Products And Raw materials |
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