CP466722
| 中文名称 | CP466722 |
|---|---|
| 中文同义词 | 1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺;ATM激酶抑制剂(CP-466722);化合物CP466722;CP-466722,ATM抑制剂 |
| 英文名称 | CP466722 |
| 英文同义词 | CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;CP-466722;CP466722;1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine;CP466722;CP 466722;CP-466722 |
| CAS号 | 1080622-86-1 |
| 分子式 | C17H15N7O2 |
| 分子量 | 349.35 |
| EINECS号 | 808-414-0 |
| 相关类别 | DNA损伤;小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors |
| Mol文件 | 1080622-86-1.mol |
| 结构式 |  |
CP466722 性质
| 沸点 | 642.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.48 |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | DMSO：可溶，0.5mg/mL，澄清（加热） |
| 酸度系数(pKa) | 0.00±0.19(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
CP-466722是一种有效的，可逆的ATM抑制剂，不影响ATR，且抑制PI3K或PIKK家族成员。In vitro, CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1–101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases. In HeLa cells, CP-466722 at doses of 6μM, results in the inhibition in ATM-dependent phosphorylation by reversibly inhibiting ionizing radiation (IR)-induced ATM kinase activity. Besides, ATM-dependent p53 induction is also inhibited by CP-466722 in MCF-7 human breast cancer cells and primary and immortalized diploid human fibroblasts. In response to IR, CP-466722 increased proportion of cells with G2/M DNA content and reduces proportion of cells with G1-phase DNA content in HeLa cells. Transient exposure to CP-466722 for a period of 4 hours sensitizes HeLa cells to IR without affecting cell plating nor cell viability.
|
ATM 4.1 μM (IC 50 ) |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-11002 | CP466722 CP-466722 | 1080622-86-1 | 5mg | 800元 |
| 2024/01/25 | HY-11002 | CP466722 CP-466722 | 1080622-86-1 | 10mg | 1400元 |