ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Antiviral drugs >Asunaprevir

Asunaprevir

Asunaprevir Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:(1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide
CAS:630420-16-5
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:630420-16-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Asunaprevir API
CAS:630420-16-5
Purity:99% Package:1KG;10USD
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Asunaprevir
CAS:630420-16-5
Purity:99% Package:1kg;2USD
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:BMS 650032
CAS:630420-16-5
Purity:98% HPLC LCMS Package:10G;20G

Lastest Price from Asunaprevir manufacturers

  • Asunaprevir
  • US $2.00 / kg
  • 2019-07-06
  • CAS:630420-16-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
  • Asunaprevir API
  • US $10.00 / KG
  • 2019-01-15
  • CAS:630420-16-5
  • Min. Order: 10G
  • Purity: 99%
  • Supply Ability: 10kg
Asunaprevir Basic information
Product Name:Asunaprevir
Synonyms:(1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide;Asunaprevir;BMS 650032;Asunaprevir (BMS-650032);BMS 650032/Asunaprevir;Asunaprevir API
CAS:630420-16-5
MF:C35H46ClN5O9S
MW:748.28584
EINECS:681-328-7
Product Categories:API;-
Mol File:630420-16-5.mol
Asunaprevir Structure
Asunaprevir Chemical Properties
density 1.37
Safety Information
MSDS Information
Asunaprevir Usage And Synthesis
Enzyme inhibitorThis highly selective HCV antiviral (FW = 748.29 g/mol; CAS 630420-16- 5; Symbol: ASV), also named BMS-650032, targets NS3 protease, a serine proteinase required for Hepatitis C Virus (HCV) polyprotein processing, showing good antiviral activity against replicons based on HCV Genotype 1a (EC50 = 4 nM), Genotype 1b (EC50 = 1.2 nM), Genotype 4 (EC50 = 1.8 nM), Genotype 5 (EC50 = 1.7 nM), and Genotype 6 (EC50 = 0.9 nM). It is far less effective against Genotype 2 (EC50 = 67 nM) and Genotype 3 (EC50 = >1100 nM). Asunaprevir is a peptidomimetic that occupies the active site, inhibiting the HCV NS3/4A serine protease, with little or no action against related viruses. The average Ki for ASV is approximately 0.4 nM and 0.2 nM for Genotype 1a and Genotype 1b, respectively. Its acylsulfonamide moeity interacts noncovalently with the NS3 protease – unlike telaprevir’s α-ketoamide moiety, which is linked covalently to NS3/4A’s catalytic serine and reverses slowly over time. ASV exhibits an excellent selectivity index (>40,000x) against all serine/cysteine proteases evaluated, including human leukocyte elastase, porcine pancreatic elastase, and three members of the chymotrypsin family. Although ASV shows a low barrier to resistance, it can be combined with daclatasvir to achieve a very high rate of viral eradication in both na?ve and treatment-experienced patients, showing a sustained virological response rate of 80%-90%.
Asunaprevir Preparation Products And Raw materials
Tag:Asunaprevir(630420-16-5) Related Product Information
Isoquinoline, 1,7-dichloro-4-Methoxy- CyclopropanecarboxaMide, 1-aMino-N-(cyclopropylsulfonyl)-2-ethenyl-,(1R,2S)-, 4-Methylbenzenesulfonate(1:1) t-Butyl(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamate