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| | Eprazinone dihydrochloride Basic information |
| Product Name: | Eprazinone dihydrochloride | | Synonyms: | EPRAZINONE HYDROCHLORIDE;3-[4-(beta-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride;1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-, dihydrochloride;746CE;Eftapan;Mucitux;NSC 317935;Propiophenone, 3-[4-(β-ethoxyphenethyl)-1-piperazinyl]-2-methyl-, dihydrochloride (8CI) | | CAS: | 10402-53-6 | | MF: | C24H33ClN2O2 | | MW: | 416.99 | | EINECS: | 233-872-8 | | Product Categories: | Inhibitors | | Mol File: | 10402-53-6.mol |  |
| | Eprazinone dihydrochloride Chemical Properties |
| Melting point | 201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White |
| Toxicity | LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher) |
| | Eprazinone dihydrochloride Usage And Synthesis |
| Originator | Mucitux,Riom,France,1969 | | Uses | Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis. | | Definition | ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid. | | Manufacturing Process | 61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g
(0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and
0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The
product is allowed to crystallize, then filtered and washed with alcohol. It is
dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water.
Yield: 66%. Melting point: 160°C. | | Therapeutic Function | Antitussive |
| | Eprazinone dihydrochloride Preparation Products And Raw materials |
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