盐酸索他洛尔
| 中文名称 | 盐酸索他洛尔 |
|---|---|
| 中文同义词 | 4'-(1-羟基-2-异丙胺乙基)甲磺酸苯胺盐酸盐;盐酸索他洛尔;N-{4-[1-羟基-2-(异丙基氨基)乙基]苯基}甲烷磺酰胺;盐酸索他洛尔溶液, 100PPM;N-[4-[1-羟基-2-(异丙基氨基)乙基]苯基]甲盐酸;索他洛尔杂质;盐酸索他洛尔 标准品;盐酸索他洛尔 USP标准品 |
| 英文名称 | Sotalol hydrochloride |
| 英文同义词 | 4-(2-isopropylamino-1-hydroxyaethyl)methanesulfonailidhydrochlorid;4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilidemonohydrochloride;4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilidmonohydrochlorid;isopropylaminohydroxyethylmethanesulfonanilidehydrochloride;meadjohnson1999;n-isopropyl-beta-(4-methanesulfonamidophenyl)ethanolaminehydrochloride;SOTACOR;SOTALEX |
| CAS号 | 959-24-0 |
| 分子式 | C12H21ClN2O3S |
| 分子量 | 308.82 |
| EINECS号 | 213-496-0 |
| 相关类别 | 医药原料;小分子抑制剂;医药原料药-科研原料;化合物：原料药;标准品;API's;Adrenoceptor;Amines;Aromatics;Sulfur & Selenium Compounds;EXCENEL;医药原料药;原料药;精细化工原料;医用原料;Miscellaneous Natural Products;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 959-24-0.mol |
| 结构式 |  |
盐酸索他洛尔 性质
| 熔点 | 218-220°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 在水中的溶解度20 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol. |
| CAS 数据库 | 959-24-0(CAS DataBase Reference) |
1.转复，预防室上性心动过速，特别是房室结折返性心动过速也可用于予激综合征伴室上性心动过速。
2.心房扑动，心房颤动。
3.各种室性心律失常，包括室性早搏，持续性及非持续性室性心动过速。
4.急性心肌梗死并发严重心律失常。
| Target | Value |
| β-adrenergic receptor | |
| Potassium channel |
Sotalol hydrochloride (MJ 1999) is an adrenergic β-antagonist that is used in the treatment of life-threatening arrhythmias. Sotalol hydrochloride is a competitive beta adrenoceptor antagonist devoid of membrane-stabilizing activity and intrinsic sympathomimetic activity that has no preferential actions on beta 1 or beta 2 responses. Sotalol hydrochloride causes concentration-dependent increases in the contractility of isolated ventricular tissue that is not blocked by previous beta or alpha blockade or catecholamine depletion. Sotalol hydrochloride consistently reduces the heart rate to a greater degree than propranolol and causes significantly less cardiac suppression than propranolol at a given heart rate.
Sotalol hydrochloride is not only a beta blocker but a class III antiarrhythmic drug. Its possible antifibrillatory activity was therefore investigated in both the ventricles and atria of dog heart in situ, since vulnerability to fibrillation is not the same in both these parts of the myocardium.
安全信息
| 提供商 | 语言 |
|---|---|
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英文
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盐酸索他洛尔 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B0437 | Sotalol hydrochloride | 5 mg | 250元 | |
| 2024/01/25 | HY-B0437 | 盐酸索他洛尔 Sotalol hydrochloride | 959-24-0 | 10mM * 1mLin DMSO | 275元 |