盐酸塞利洛尔
中文名称 | 盐酸塞利洛尔 |
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中文同义词 | 2,2,3,3,4,4,5,5,6-九溴联苯醚;盐酸塞利洛尔;3-[3-乙酰-4-(3-叔丁胺基)-2-羟基丙氧基]苯基-1,1-二乙基脲盐酸盐;得来恩;塞利洛尔峰鉴别 EP标准品;盐酸塞利洛尔 EP标准品;1-二氯乙烯;2-双(4-氯苯基)-1 |
英文名称 | Celiprolol hydrochloride |
英文同义词 | ffhcl;rhc-5320a;selectrol;st1396clorhidrato;st1396hydrochlorid;st1396hydrochloride;3-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-1,1-ure;3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylharnsto |
CAS号 | 57470-78-7 |
分子式 | C20H34ClN3O4 |
分子量 | 415.95 |
EINECS号 | 260-752-2 |
相关类别 | 小分子抑制剂;盐酸塞利洛尔(标准品);抑制剂;原料;医药原料药;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 57470-78-7.mol |
结构式 |
盐酸塞利洛尔 性质
熔点 | 197-200°C (dec.) |
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RTECS号 | YR6560000 |
储存条件 | Refrigerator |
溶解度 | 易溶于水和甲醇,溶于乙醇(96%),极微溶于二氯甲烷。 |
形态 | 固体 |
颜色 | 白色至类白色 |
水溶解性 | Soluble in ethanol, methanol and water |
CAS 数据库 | 57470-78-7(CAS DataBase Reference) |
Celiprolol是β1-adrenoceptor拮抗剂,具有部分β2受体激动剂活性。
β1-andrenoceptor
Celiprolol (5 or 50 mg/kg; p.o. every day for 12 weeks) has a moderate antihypertensive action at the dose of 50 mg/kg, and significantly reduces media smooth muscle hypertrophy of the mesenteric artery in SHR.
Animal Model: | Male spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats (8 weeks old) |
Dosage: | 5, 50 mg/kg |
Administration: | P.o. every day (administered in drinking water) for 12 weeks |
Result: |
Attenuated the rise in blood pressure significantly at the dose of 50 mg/kg in SHR.
Did not significantly affect absolute heart or body weights. Reduced the average medial thickness of the mesenteric artery in SHR. |
用途
抗高血压药。安全信息
毒性 | LD50 in male mice, rats (mg/kg): 56.2, 68.3 i.v.; 1834, 3826 orally (Wendtlandt, Pittner) |
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盐酸塞利洛尔 化学药品说明书
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S5923 | 盐酸塞利洛尔 Celiprolol hydrochloride | 57470-78-7 | 2mg | 795.34元 |
2024/08/19 | S5923 | Celiprolol hydrochloride | 57470-78-7 | 10mg | 1777.23元 |