57470-78-7
中文名称
盐酸塞利洛尔
英文名称
Celiprolol hydrochloride
CAS
57470-78-7
EINECS 编号
260-752-2
分子式
C20H34ClN3O4
MDL 编号
MFCD00941500
分子量
415.95
MOL 文件
57470-78-7.mol
更新日期
2026/01/19 10:20:13
57470-78-7 结构式
基本信息
中文别名
3-[3-乙酰-4-(3-叔丁胺基)-2-羟基丙氧基]苯基-1,1-二乙基脲盐酸盐盐酸塞利洛尔
2,2,3,3,4,4,5,5,6-九溴联苯醚
英文别名
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea hydrochlorideCELIPROLOL HYDROCHLORIDE
3-(3-acetil-4-(3-tert-butilamino-2-hidroxipropoxi)fenil)-1,1-dietilureahcl
3-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-1,1-ure
3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylharnsto
3-(3-acetyl-4-(3-tert-butylamino-2-hydroxypropoxy)phenyl)-1,1-diethylureahyd
celiprololclorhidrato
celiprololhydrochlorid
clorhidratodeceliprolol
ffhcl
rhc-5320a
selectrol
st1396clorhidrato
st1396hydrochlorid
st1396hydrochloride
Celipolol Hydrochloride
3-[3-acetyl-4-[3-[(tert-butyl)amino]-2-hydroxypropoxy]phenyl]-1,1-diethyluronium chloride
Urea, N-3-acetyl-4-3-(1,1-dimethylethyl)amino-2-hydroxypropoxyphenyl-N,N-diethyl-, monohydrochloride
CELIPOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)
Celectol
所属类别
原料药：抗心律失常药物理化学性质
熔点197-200°C (dec.)
RTECS号YR6560000
储存条件Refrigerator
溶解度Freely soluble in water and in methanol, soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.
形态neat
颜色白色至灰白色
水溶解性Soluble in ethanol, methanol and water
InChI1S/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H
InChIKeyVKJHTUVLJYWAEY-UHFFFAOYSA-N
SMILES[Cl-].N(CC)(CC)C(=O)Nc1cc(c(cc1)OCC(O)CNC(C)(C)C)C(=O)C.[H+]
安全数据
警示词警告
危险性描述H303
WGK GermanyWGK 3
存储类别11 - Combustible Solids
毒性LD50 in male mice, rats (mg/kg): 56.2, 68.3 i.v.; 1834, 3826 orally (Wendtlandt, Pittner)
盐酸塞利洛尔价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/09/19 | S5923 | 盐酸塞利洛尔 Celiprolol hydrochloride | 57470-78-7 | 2mg | 795.34元 |
| 2025/09/19 | S5923 | 盐酸塞利洛尔 Celiprolol hydrochloride | 57470-78-7 | 10mg | 1777.23元 |
常见问题列表
生物活性
Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。靶点
β1-andrenoceptor
体内研究
Celiprolol (5 or 50 mg/kg; p.o. every day for 12 weeks) has a moderate antihypertensive action at the dose of 50 mg/kg, and significantly reduces media smooth muscle hypertrophy of the mesenteric artery in SHR.
| Animal Model: | Male spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats (8 weeks old) |
| Dosage: | 5, 50 mg/kg |
| Administration: | P.o. every day (administered in drinking water) for 12 weeks |
| Result: |
Attenuated the rise in blood pressure significantly at the dose of 50 mg/kg in SHR.
Did not significantly affect absolute heart or body weights. Reduced the average medial thickness of the mesenteric artery in SHR. |