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4-Aminopyridine Suppliers list
Company Name: Hangzhou Cyanochem Co., Ltd.
Tel: +86 17788583750
Products Intro: Product Name:4-Aminopyridine
Purity:98% Package:100g;300g;1KG,5KG;25KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:4-Aminopyridine
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:504-24-5
Purity:0.99 Package:25KG,5KG;1KG;500G
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: CAS:504-24-5
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Zjartschem
Tel: +86-571-8723 8903
Products Intro: Product Name:4-Aminopyridine
Purity:98% Package:500g;1kg;5kg;10kg;100kg;1000kg... Remarks:Brand:Zjartschem | Cat.No.:ZCF07226

Lastest Price from 4-Aminopyridine manufacturers

  • 4-Aminopyridine
  • US $63.50 / KG
  • 2019-07-06
  • CAS:504-24-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100ton
4-Aminopyridine Basic information
Product Name:4-Aminopyridine
Synonyms:4-amino-pyridin;Avitrol 200;avitrol200;Compound 1861;Frampridine;mi-w-3;4-AP;4APY
Product Categories:amine;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals;Pyridine;Organics;SERMION;Azetidines;Amines;Pyridines;Pyridines derivates;Heterocyclic Compounds;A;Alphabetical Listings;Stable Isotopes;Potassium channel;Ion Channels
Mol File:504-24-5.mol
4-Aminopyridine Structure
4-Aminopyridine Chemical Properties
Melting point 157 °C
Boiling point 273 °C(lit.)
density 1.26
refractive index 1.5560 (estimate)
Fp 156°C
storage temp. 0-6°C
solubility H2O: soluble50mg/mL, clear, colorless
pka9.114(at 25℃)
form Crystalline Powder, Solid or Crystals
color White to faint grey to light yellow
Water Solubility Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck 14,3933
BRN 105782
CAS DataBase Reference504-24-5(CAS DataBase Reference)
NIST Chemistry Reference4-Pyridinamine(504-24-5)
EPA Substance Registry System4-Aminopyridine (504-24-5)
Safety Information
Hazard Codes T+,N,T,Xi
Risk Statements 28-36/37/38-51/53-23/24/25
Safety Statements 26-36/37/39-45-60-61-37/39-28A-1
RIDADR UN 2671 6.1/PG 2
WGK Germany 3
RTECS US1750000
Autoignition Temperature640 °C
Hazard Note Toxic/Irritant
HazardClass 6.1
PackingGroup II
HS Code 29333999
Hazardous Substances Data504-24-5(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 21 mg/kg
MSDS Information
4-Aminopyridine English
SigmaAldrich English
ALFA English
4-Aminopyridine Usage And Synthesis
DescriptionDalfampridine (also referred to as 4-AP) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.
Chemical Properties4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.
Chemical Properties4-Aminopyridine is white to tan or brown crystalline material. Odorless.
OriginatorRush University Medical Center (United States)
UsesDalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.
DefinitionChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Brand nameNeurelan (E′lan);Ampyra.
General DescriptionWhite crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.
Reactivity Profile4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health HazardMaterial may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.
Health Hazard4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks
Fire HazardMaterial may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.
Safety ProfilePoison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.
Potential ExposureUsed as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison
ShippingUN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Purification MethodsCrystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]
IncompatibilitiesSodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.
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