ChemicalBook > Product Catalog >API >Blood System Drugs >Haemostatic Drugs >6-Aminocaproic acid

6-Aminocaproic acid

6-Aminocaproic acid Suppliers list
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:6-Aminocaproic acid
Purity:99 Package:1KG;40USD|10KG;308USD
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Products Intro: Product Name:6-Aminocaproic acid
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Yancheng Green Chemicals Co.,Ltd
Tel: 86-25-86655873
Products Intro: Product Name:6-Aminocaproic acid
Purity:99 Package:25KG;0USD
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Products Intro: Product Name:6-Aminocaproic acid
Purity:As coa Package:As request Remarks:60-32-2
Company Name: Guangzhou PI PI Biotech Inc
Tel: ;
Products Intro: Product Name:Aminocaproic Acid
Purity:90%+ Package:10mg;0USD|25mg;0USD|50mg;0USD|100mg;0USD

Lastest Price from 6-Aminocaproic acid manufacturers

  • Aminocaproic Acid
  • US $0.00-0.00 / mg
  • 2021-09-19
  • CAS:60-32-2
  • Min. Order: 10mg
  • Purity: 90%+
  • Supply Ability: 10g
  • 6-Aminocaproic acid
  • US $10.00-100.00 / KG
  • 2021-09-02
  • CAS:60-32-2
  • Min. Order: 0.5KG
  • Purity: >99%
  • Supply Ability: 20tons
  • 6-Aminocaproic Acid
  • US $10.00 / Kg/Drum
  • 2021-08-26
  • CAS:60-32-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 10 ton
6-Aminocaproic acid Basic information
Description References
Product Name:6-Aminocaproic acid
Synonyms:177 J.D;177 J.D.;177j.d.;177jd;6-amino-hexanoicaci;Acepramin;Acepramine;ACS
Product Categories:omega-Aminocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Amino Acids;Organic acids;Fibrinogen/Thrombin;Pharmaceutical raw materials;AMICAR
Mol File:60-32-2.mol
6-Aminocaproic acid Structure
6-Aminocaproic acid Chemical Properties
Melting point 207-209 °C (dec.) (lit.)
Boiling point 242.49°C (rough estimate)
density 1.042 g/cm3
vapor pressure <0.1 hPa (20 °C)
refractive index 1.4870 (estimate)
Fp 207-209°C
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
form powder
pka4.373(at 25℃)
color white
PH7.0-7.5 (50g/l, H2O, 20℃)
Water Solubility SOLUBLE
Merck 14,432
BRN 906872
CAS DataBase Reference60-32-2(CAS DataBase Reference)
NIST Chemistry ReferenceHexanoic acid, 6-amino-(60-32-2)
EPA Substance Registry SystemHexanoic acid, 6-amino- (60-32-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
RTECS MO6300000
HS Code 29224995
Hazardous Substances Data60-32-2(Hazardous Substances Data)
ToxicityLD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
MSDS Information
6-Aminohexanoic acid English
SigmaAldrich English
ACROS English
ALFA English
6-Aminocaproic acid Usage And Synthesis
Description6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease.
Chemical Propertieswhite crystalline powder
OriginatorEpsilon,Roche,W. Germany,1962
Uses6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.
UsesPropylparaben Food preservative
UsesEACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
DefinitionChEBI: An amino-acid anion that is the conjugate base of 6-aminohexanoic acid.
Manufacturing Process5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.
Brand nameAmicar (Xanodyne).
Therapeutic FunctionAntifibrinolytic
Mechanism of actionBecause binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.
Safety ProfileModerately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.
Chemical SynthesisAminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam at high temperature.

Veterinary Drugs and TreatmentsAminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.
6-Aminocaproic acid Preparation Products And Raw materials
Raw materialsAmmonium hydroxide-->Caprolactam-->AMBERLITE IR-120-->Water
Preparation ProductsGabexate mesylate-->Capobenic acid-->N-tert-Butoxycarbonyl-1,6-hexanediamine
Tag:6-Aminocaproic acid(60-32-2) Related Product Information
6-AMINO-HEXANOIC ACID ETHYL ESTER LABOTEST-BB LT00451924 GLY-HIS-LYS ACETATE SALT D(+)-Pipecolinic acid L(+)-Homoarginine hydrochloride DL-PIPECOLIC ACID HYDROCHLORIDE N6-Cbz-L-Lysine 5-HYDROXY-DL-LYSINE HYDROCHLORIDE Ethyl pipecolinate Ethyl 1-methylpipecolinate AC-LYS-OH 2,6-DIAMINOPIMELIC ACID N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate H-LYS(ME)-OH HCL N-EPSILON-ACETYL-L-LYSINE N-Benzyloxycarbonyl-6-aminohexanoic acid 6-Acetamidohexanoic acid D-Lysine