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Isobutyronitrile Basic information
Product Name:Isobutyronitrile
Product Categories:Organics
Mol File:78-82-0.mol
Isobutyronitrile Structure
Isobutyronitrile Chemical Properties
Melting point -72 °C
Boiling point 107-108 °C(lit.)
density 0.770 g/mL at 20 °C(lit.)
vapor density 2.38 (vs air)
vapor pressure 100 mm Hg ( 54.4 °C)
refractive index n20/D 1.372(lit.)
Fp 39 °F
storage temp. Flammables area
form Liquid
color Clear colorless to light yellow
Water Solubility 35 g/L (20 ºC)
Merck 14,5156
BRN 1340512
Stability:Stable. Flammable. May form explosive mixtures with air. Incompatible with strong oxidizing agents.
CAS DataBase Reference78-82-0(CAS DataBase Reference)
NIST Chemistry ReferencePropanenitrile, 2-methyl-(78-82-0)
EPA Substance Registry SystemPropanenitrile, 2-methyl-(78-82-0)
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-36/37/38
Safety Statements 9-16-24/25-26-36/37/39-45-23
RIDADR UN 2284 3/PG 2
WGK Germany 2
RTECS TZ4900000
Hazard Note Highly Flammable/Toxic
HazardClass 3
PackingGroup II
Hazardous Substances Data78-82-0(Hazardous Substances Data)
ToxicityLD50 (mg/kg): 25 i.p. in mice; 200 orally in rats (Zeller); LD50 orally in male mice: 0.3652 mmol/kg (Tanii)
MSDS Information
SigmaAldrich English
ALFA English
Isobutyronitrile Usage And Synthesis
Chemical Propertiescolourless liquid
General DescriptionA clear colorless liquid. Flash point 47°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.
Air & Water ReactionsHighly flammable. Slightly soluble in water.
Reactivity ProfileIsobutyronitrile is incompatible with the following: Oxidizers, reducing agents, strong acids & bases .
Health HazardPoisonous; may be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes. (Non-Specific -- Nitriles) Primarily, they are skin and eye irritants. Large doses cause collapse and stop breathing.
Fire HazardVapor may explode if ignited in an enclosed area. Toxic oxides of nitrogen are produced during combustion. Isobutyronitrile is a flammable/combustible material and may be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Hazardous polymerization may not occur.
Purification MethodsShake the nitrile with conc HCl (to remove isonitriles), then with water and aqueous NaHCO3. After a preliminary drying with silica gel or Linde type 4A molecular sieves, it is shaken or stirred with CaH2 until hydrogen evolution ceases, then decanted and distilled from P2O5 (not more than 5g/L, to minimize gel formation) or Drierite (b 101-103o/760mm). Finally it is refluxed with, and slowly distilled from CaH2 (5g/L), taking precautions to exclude moisture. [Beilstein 2 H 294, 2 I 129, 2 II 263, 2 III 655, 2 IV 853.]
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