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L-Valine

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Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: sales@jushengtech.com
Products Intro: Product Name:L-valine
CAS:72-18-4
Purity:99% Package:5KG;1KG Remarks:C5H11NO2
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:L-Valine
CAS:72-18-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:L-Valine
CAS:72-18-4
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:L-Valine
CAS:72-18-4
Purity:USP24 Package:1Kg;25kg/ Drum or as customer request Remarks:white crystalline
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:L-Valine
CAS:72-18-4
Purity:0.99 Package:25KG,5KG;1KG;500G

Lastest Price from L-Valine manufacturers

  • L-Valine
  • US $0.00 / mg
  • 2019-12-27
  • CAS:72-18-4
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
  • L-Valine
  • US $1.00 / g
  • 2019-07-31
  • CAS:72-18-4
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 1000 Kilogram/Kilograms per Week
  • L-Valine
  • US $100.00 / KG
  • 2019-07-06
  • CAS:72-18-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: Customized

Related articles

  • Biological activity of L-Valine
  • L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classifie....
  • Oct 16,2019
L-Valine Basic information
Amino acids Content Analysis Chemical property Uses
Product Name:L-Valine
Synonyms:L-Valine (High Purity );2,3-D2);L-Valine, Animal-Free;L-VALINE BIOULTRA, >= 99.5% (NT);L-VALINE, REAGENT GRADE, >=98% (HPLC;L-ValineUSP, 98.5-101.5% (Titration: anhydrous basis);L-Valine,99%e.e.;(S)-(+)-VALINE
CAS:72-18-4
MF:C5H11NO2
MW:117.15
EINECS:200-773-6
Product Categories:Amino Acids;Amino Acid Derivatives;Valine [Val, V];Amino Acids and Derivatives;alpha-Amino Acids;Biochemistry;Nutritional Supplements;Amino Acids;amino
Mol File:72-18-4.mol
L-Valine Structure
L-Valine Chemical Properties
Melting point 295-300 °C (subl.)(lit.)
alpha 28 º (c=8, 6N HCl)
Boiling point 213.6±23.0 °C(Predicted)
density 1.23
refractive index 28 ° (C=8, HCl)
storage temp. Store at RT.
solubility H2O: 25 mg/mL
pka2.29(at 25℃)
form powder
color White
PH5.5-6.5 (100g/l, H2O, 20℃)
optical activity[α]20/D +27.0±0.5°, c = 5% in 5 M HCl
Water Solubility 85 g/L (20 ºC)
λmaxλ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.1
Merck 14,9909
BRN 1721136
InChIKeyKZSNJWFQEVHDMF-BYPYZUCNSA-N
CAS DataBase Reference72-18-4(CAS DataBase Reference)
NIST Chemistry ReferenceValine(72-18-4)
EPA Substance Registry SystemL-Valine (72-18-4)
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 24/25-36-22
WGK Germany 3
RTECS YV9361000
TSCA Yes
HS Code 29224995
ToxicityLD50 intraperitoneal in rat: 5390mg/kg
MSDS Information
ProviderLanguage
2-Aminoisovaleric acid English
ACROS English
SigmaAldrich English
ALFA English
L-Valine Usage And Synthesis
Amino acidsL-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.
Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.
L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.
Content AnalysisAbout 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2).
Chemical propertyWhite crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).
Uses
  • Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction.
  • L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives.
  • Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine.
DescriptionValine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes.
Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation.
Chemical PropertiesWhite or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.
UsesL-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grai ns, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.
Usesvaline is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.
DefinitionChEBI: The L-enantiomer of valine.
BiosynthesisValine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include :
Acetolactate synthase
Acetohydroxy acid isomeroreductase
Dihydroxyacid dehydratase
Valine aminotransferase.
Safety ProfileMutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Chemical SynthesisRacemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative
HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr
HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br
.
Purification MethodsCrystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.]
NomenclatureAccording to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.
Tag:L-Valine(72-18-4) Related Product Information
DL-Phenylalanine L-Proline L(+)-Arginine Lithium bis(trimethylsilyl)amide METHYL 4-(4-AMINOPHENYL)BUTANOATE ALTRENOGEST phosphoric acid N,N-Dimethyl-1,4-phenylenediamine 4-Aminobutyric acid L-Valine methyl ester hydrochloride Glycine Folic acid Valine (S)-2-(Boc-amino)-3-methylbutyric acid DL-Valine Isovaleric acid AMINO ACIDS L-Valine