L-Triiodothyronine(T3), Liothyronine Sodium

Item

Specification

Result

Appearance

An odorless, almost white or buff colored powder

pass

Solubility

1,Very slightly soluble in water

pass

2,slightly soluble in alcohol

pass

3,practically insoluble in most other organic solvents

pass

4,disolves in diluted aqueous sodium hydroxide solutions

Pass

Identificaton

a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved.

pass

b)The retention time of the major peak is confirm to the RS

pass

Loss on Drying

Not more than 4.0%

0.46%

[a]20/D

C=1 in 1M HCl/EtOH 1:4

+18 ~ +22o

+20.9o

Assay(HPLC)

Not less than 95.0%

99.18%

Levothyroxine sodium

Not more than 5.0%