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Postion:Product Catalog >API>Digestive system drugs>Antacid and Mucosal protective Drugs>Olsalazine sodium
Olsalazine sodium
  • Olsalazine sodium

Olsalazine sodium

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Olsalazine sodium CAS No.: 6054-98-4
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

Olsalazine sodium Basic information
Treatment of acute and chronic colitis Adverse reaction
Product Name: Olsalazine sodium
Synonyms: 3,3’-azobis[6-hydroxy-benzoicacidisodiumsalt;Benzoicacid,3,3’-azobis[6-hydroxy-,disodiumsalt;olsalazinedisodiumsalt;OLSALAZINE DISODIUM;OLSALAZINE SODIUM;disodium 5,5'-azodisalicylate;Acid mordant Yellow 5;Chrome Yellow AS
CAS: 6054-98-4
MF: C14H8N2O6.2Na
MW: 346.2
EINECS: 227-975-7
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Pharmaceutical intermediate;API;AZODISAL SODIUM
Mol File: 6054-98-4.mol
Article illustration
 
Olsalazine sodium Chemical Properties
Melting point  240 °C
storage temp.  -20°C Freezer
CAS DataBase Reference 6054-98-4(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt(6054-98-4)
 
Safety Information
MSDS Information
 
 
Olsalazine sodium Usage And Synthesis
Treatment of acute and chronic colitis Olsalazine sodium is a drug developed by Pharmacia A B Co., Switzerland, to treat acute and chronic colitis. It was first listed in Denmark in 1989. It has been collected and recordedby the European Pharmacopoeia 7 edition and the national drug standard WS1- (X-349) -2004Z. Orsalazine sodium is a precursor drug consisting of two azo bonds linked to 5- amino salicylic acid. The bacteria in the colon break up the diazo bond and release 5- amino salicylic acid. 5- amino salicylic acid acts on colitis mucosa, inhibits the formation of prostaglandins, leukotrienes and other inflammatory factors, and reduces membrane permeability, and plays a role in the treatment of ulcerative colitis. This product weakens the absorption of nitrogen, sodium and water in the ileum and colonic mucosa, which is transformed into secretion in human body. Patients with ulcerative colitis take 1g daily, and the whole intestinal transit time is shortened by 40%.  If the healthy subjects are given oral administration of 2g once, It has no effect on the complex frequency of migration of the small intestine. But it can cause diarrhea in 30% of the users and increase the diarrhea of the patients with intestinal inflammation.  The bioavailability of the whole body is extremely low. The absorption rate of the oral dose is less than 5%.
After absorption, about 10% doses will be conjugated to orsalazine sulfate, t1/2 about 1H and conjugated half life is about 7 days.Article illustration
Figure 1 The structural formula of oralalazine sodium
Adverse reaction The most common side effect is diarrhoea, the incidence of which is 17%. Usually, the difference between diarrhea and intestinal inflammation is that the excreta has high water content without blood, and is related to the dosage. It usually occurs when the treatment begins or the dose increases. Reduction the dose of this product or combined use with Loperamide, diarrhea will be controlled. Other side effects include headache, nausea, abdominal pain, rash, dizziness and joint pain. Most of the patients who are allergic or intolerant to sulfasalazine are resistant to this product. The male sterility treated with sulfasalazine improved after using this product.
Chemical Properties Yellow Crystalline Powder
Uses Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis
Uses Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.
Definition ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical
Uses Mordant dye for wool.
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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