Bupivacaine
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Update Time: | 2019-12-20 |
Product Details
| Product Name: Bupivacaine | CAS No.: 2180-92-9 |
| EC-No.: 218-553-3 | Min. Order: 1g |
| Purity: 99% | Supply Ability: g/kg/T |
| Release date: 2019/12/20 |
Heidi 147
Tel: +86-371-56618766
Fax: +86-371-86658258
Mob: +86-18607162328
Email: heidi@coreychem.com
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Bupivacaine Basic information
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Product Name:
Bupivacaine
Synonyms:
MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamid
CAS:
2180-92-9
MF:
C18H28N2O
MW:
288.43
EINECS:
218-553-3
Product Categories:
Active Pharmaceutical Ingredients;research chemical
Mol File:
2180-92-9.mol
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Bupivacaine Chemical Properties
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Melting point
107.5-108°
Boiling point
430.65°C (rough estimate)
density
1.0238 (rough estimate)
refractive index
1.5700 (estimate)
pka
8.09; also reported as 8.17(at 25℃)
CAS DataBase Reference
2180-92-9(CAS DataBase Reference)
NIST Chemistry Reference
2-Piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-(2180-92-9)
EPA Substance Registry System
2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- (2180-92-9)
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Safety Information
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Hazard Codes
T+
Risk Statements
26/27/28-38-41
Safety Statements
22-26-36/37/39-45
RIDADR
2811
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MSDS Information
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Bupivacaine Usage And Synthesis
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Uses
Anesthetic (local).
Brand name
Marcaine (Hospira); Sensorcaine (AstraZeneca).
General Description
Bupivacaine was synthesized simultaneously with mepivacainein 1957 but was at first overlooked because of the increasedtoxicity compared with mepivacaine. When themethyl on the cyclic amine of mepivacaine is exchanged fora butyl group the lipophilicity, potency and the duration ofaction all increase. Literature reports of cardiovascular toxicity,including severe hypotension and bradycardia, areabundant in the literature.91 Bupivacaine is highly bound toplasma proteins (95%), and thus the free concentration mayremain low until all of the protein binding sites are occupied.After that point, the plasma levels of bupivacaine rise rapidlyand patients may progress to overt cardiac toxicity withoutever showing signs of CNS toxicity. The cardiotoxicity ofbupivacaine is a result of its affinity to cardiac tissues and itsability to depress electrical conduction and predispose theheart to reentry types of arrhythmias. The cardiotoxicity ofbupivacaine was found to be significantly more prominentwith the “R” isomer, or the racemic mixture, thus the “S”stereoisomer is now on the market as levobupivacaine.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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