Guanidine hydrochloride NEW

Guanidinium chloride or guanidine hydrochloride, usually abbreviated GdmCl and sometimes GndCl or GuHCl, is the hydrochloride salt of guanidine.

Character

Preparation method: 

Guanidine hydrochloride preparation method, with the following process: 

a, melting, the weight ratio of 1∶1.27 dicyandiamide and ammonium chloride into the reactor, melting reaction at 170 ~ 230℃, guanidine hydrochloride crude product; 

b, dissolve, at room temperature, dissolve guanidine hydrochloride in water at a ratio of 1 to 1, and add ammonium salt alkali to the solution according to the content of ammonium salt in guanidine hydrochloride; 

c, filtration, the raw materials and reaction by-products are removed by filtration method; 

d, dehydration, the filtered mother liquor at high temperature dehydration; 

e, crystallization, supersaturated solution cooling, concentrated crystallization, to obtain high-purity guanidine hydrochloride. 

f, the guanidine hydrochloride after step e is added into the dicyandiamide into the reactor, the melting reaction is carried out at 170 ~ 230℃ for 3 ~ 4h, and then through steps b, c, d, e, to obtain higher purity guanidine hydrochloride, and this step can be repeated several times according to needs. g. The guanidine hydrochloride after step e is then passed through steps b, c, d and e, where the ratio of step b to water is 1.5∶1 to obtain higher purity guanidine hydrochloride, and this step can be repeated several times as needed.

Application

It is often used for denaturing proteins and refolding after denaturing proteins.

As an intermediate of medicine, pesticide, dye and other organic synthesis, it is an important raw material for manufacturing sulfanilamide drugs and folic acid, and can also be used as an antistatic agent for synthetic fiber. It is an important raw material for producing sulfadiazine, sulfadiazine, sulfadiazine and folic acid.