Bethanechol NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-21 |
Product Details
| Product Name: Bethanechol | CAS No.: 590-63-6 |
| EC-No.: 209-686-8 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/21 |
| CAS: | 590-63-6 |
| MF: | C7H17ClN2O2 |
| MW: | 196.68 |
| EINECS: | 209-686-8 |
| Product Categories: | Coumarins ,Pyrans;Inhibitors;Acetylcholine receptor;Aliphatics;Amines;DUVOID;Intermediates & Fine Chemicals;Pharmaceuticals;590-63-6 |
| Mol File: | 590-63-6.mol |
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| Bethanechol Chemical Properties |
| Melting point | 187-190°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 1.7 g/mL stable for several days at 4°C. |
| form | crystalline |
| color | white |
| Merck | 14,1185 |
| CAS DataBase Reference | 590-63-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (590-63-6) |
| Bethanechol Usage And Synthesis |
| Description | Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 μM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC50 = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract. |
| Chemical Properties | White Solid |
| Originator | Urecholine CI,MSD,US,1949 |
| Uses | cholinergic |
| Uses | A selective muscarinic receptor stimulant, used to treat cerebral palsy. |
| Uses | Therapeutic action of Betanechol is based on this action, and it is used for treating postoperational non-obstructive retention of urine and neurogenic bladder atony. Earlier, it was used for treating gastrointestinal illnesses and Alzheimer’s disease. |
| Definition | ChEBI: The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention. |
| Manufacturing Process | About 3 grams of β-methylcholine chloride are stirred at room temperature with an excess of phosgene dissolved in 50 grams of chloroform, for about 2 hours. Excess phosgene and hydrochloric acid are removed by distillation under vacuo. Additional chloroform is added to the syrup and the mixture is poured into excess ammonia dissolved in chloroform and cooled in solid carbon dioxide-acetone. The solid is filtered and extracted with hot absolute alcohol. The solid in the alcohol is precipitated with ether, filtered, and recrystallized from isopropanol. The carbaminoyl-β-methylcholine chloride obtained has a melting point of about 220°C. |
| Brand name | Duvoid (WellSpring); Myotonachol (Glenwood); Urecholine (Odyssey). |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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China- Since: 2017-12-08
- Address: Building A, Enjoy city, Zhongshan East Road, Shijiazhuang city, Hebei province
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