Cyclosporine A NEW

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Introduction

Product Name: Cyclosporine A

Other Name : Cyclosporine 

CAS NO:59865-13-3

Purity: 99%min
Appearance:White Powder

Molecular formula: C62H111N11O12

MW:1202.61

Melting Point :148-151°C

Boiling Point :838.63°C (rough estimate)

Density :0.9913 g/cm3(Predicted)

Solubility :Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.

Storage :Sealed in dry,Store in freezer, under -20°C.

Cyclosporine is a potent immunosuppressive agent that in animals prolongs survival of allogeneic transplants involving skin, kidney, liver, heart, pancreas, bone marrow, small intestine, and lung. Cyclosporine has been demonstrated to suppress some humoral immunity and to a greater extent, cell-mediated immune reactions such as allograft rejection, delayed hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, and graft versus host disease in many animal species for a variety of organs.

Application
Cyclosporine initially isolated from the fungus Tolypocladium inflatum isolated from a soil, ciclosporine is a cyclicnonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.
 
Cyclosporine widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection.