Esomeprazole sodium
| Price | $10 | $15 | $20 |
| Package | 1kg | 1kg | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 100000ton/Years |
| Update Time: | 2023-07-31 |
Product Details
| Product Name: Esomeprazole sodium | CAS No.: 161796-78-7 |
| Min. Order: 1kg | Purity: content ≧ 99% |
| Supply Ability: 100000ton/Years | Release date: 2023/07/31 |
Basic Info.
Product Description
USP 99% High Quality Pharmaceutical Material Esomeprazole Sodium CAS 161796-78-7
Introduction
| Name | Esomeprazole sodium | |
| Synonyms | 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl-1H-benzimidazole sodium salt | |
| Molecular Structure | ||
| Molecular Formula | C17H20N3NaO3S | |
| Molecular Weight | 369.41 | |
| CAS Registry Number | 161796-78-7 | |
Esomeprazole is in a group of drugs called proton pump inhibitors. Esomeprazole decreases the amount of acid produced in the stomach.
Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).
Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.
Function
Esomeprazole sodium is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.
Specification
Test items | Specifications | Result |
Appearance | White or slightly coloured powder,slight hygroscopic | almost white powder |
Identification A. IR B.Enantiomeric purity C.Reaction of maganesium D. Water |
IR Conforms to the CRS.(2.2.24) Impurity F ≤0.2%(2.2.29) It gives reaction of magnesium(2.3.1) 6.2%~8.0%(2.5.12) |
Complies 0.05% Complies 7.3% |
Absorbance | The absorbance is not greater than 0.20 at 440nm.(2.2.25) | 0.12 |
Related substances(HPLC) Impurity E Impurity D Unspecified impurities Total impurity Impurity F | (2.2.29) ≤0.15% ≤0.15% ≤0.10% ≤0.3% ≤0.2%(2.2.29) |
0.04% 0.10% 0.03% 0.2% 0.05% |
Magnesium | 3.30%~3.55% | 3.46% |
Water by K.F. | 6.2%~8.0%(2.5.12) | 7.3% |
Assay(HPLC) | 98.0%~102.0%(2.2.29) | 99.9% |
Residual solvents: a) Acetne b)Etyl aetate c)Methylene chloide d)Methnol e)Toluee f)Benzene |
Not more than 5000ppm Not more than 5000ppm Not more than 100ppm Not more than 3000ppm Not more than 890ppm Not more than 2ppm |
3ppm Not detected Not detected 77ppm Not detected Not detected |
Chemical & Physical Properties
| Boiling Point | 600ºC at 760 mmHg |
|---|---|
| Molecular Formula | C17H18N3NaO3S |
| Molecular Weight | 367.398 |
| Flash Point | 316.7ºC |
| Exact Mass | 367.096649 |
| PSA | 85.45000 |
| LogP | 3.55120 |
Store in a cool and ventilated warehouse. Keep away from fire and heat source. The storage temperature should not exceed 32 ºC, and the relative humidity should not exceed 80%. Keep away from light. The package shall be sealed and shall not come into contact with air. Provide corresponding varieties and quantities of fire-fighting equipment. The storage area shall be equipped with leakage emergency treatment equipment and appropriate receiving materials.
Company Profile Introduction
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China- Since: 2022-03-18
- Address: Room 601, Unit 1, Building 1, 188 Xinhuali, North Xinhua Road, Xiangdu District, Xingtai city, Hebei