Furosemide

Furosemide name

Furosemide in Chinese

English name furosemide

Chinese alias furosemide | thiamethoxam meters

More English nicknames

Biological activity of furosemide

Description Furosemide (Lasix) is a Na+/2Cl-/K+ (NKCC) co-transport channel inhibitor.

Related category

Signal path > > Transmembrane transport > > NKCC

Research Field > > Metabolic disease

Reference literature

[1]. Rais-Bahrami K, et al. Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug; 21 (6) : 329-32.

[2]. Tia S, et al. Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA (A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1; 16 (11) : 3630-40.

[3]. Korpi ER, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol.1995 Feb; 47 (2) : 283-9.

Physicochemical properties of furthiamide

Density 1.6± 0.1g /cm3

Boiling point 582.1±60.0 °C at 760 mmHg

Melting point 220 °C (dec.)(lit.)

Molecular formula C12H11ClN2O5S

Molecular weight 330.744

Flash point 305.9±32.9 °C

Accurate mass 330.007721

PSA 131.01000

LogP 3.10

Appearance properties white powder

Vapor pressure 0.0±1.7 mmHg at 25°C

Refractive index 1.658

Storage condition

This product should be sealed in a cool and dry place.

Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents. Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.

Molecular structure

1. Molar refractive index: 75.76

2. Molar volume (m3/mol) : 205.8

3. Isotropic volume (90.2K) : 606.2

4. Surface tension (dyne/cm) : 75.2

5, polarization (10-24cm 3) : 30.03

Computational chemistry

1. Reference value for calculating hydrophobic parameters (XlogP) : None

2. Number of hydrogen bond donors :3

3. Number of hydrogen bond receptors :7

4. Number of rotatable bonds :5

5. Number of tautomers :4

6. Topological molecular polar surface area 131

7. Number of heavy atoms :21

8. Surface charge :0

9. Complexity :481

10. Number of isotope atoms :0

11. Determine the number of primary constitutive centers :0

12. Number of indeterminate atomic orthotropic centers :0

13. Determine the number of chemical bond constitutive centers :0

14. Number of uncertain bond constitutive centers :0

15. Number of covalent bond units :1

more

1. Properties: White or white crystalline powder, odorless, almost tasteless.

2. Density (g/mL,25/4℃) : not determined

3. Relative vapor density (g/mL, air =1) : not determined

4. Melting point (ºC) : 206

5. Boiling point (ºC, atmospheric pressure) : not determined

6. Boiling point (ºC,5.2kPa) : Not determined

7. Refractive index: not determined

8. Flash point (ºC) : Not determined

9. Specific rotation (º) : Not determined

10. Spontaneous ignition point or ignition temperature (ºC) : not determined

11. Vapor pressure (kPa,25ºC) : Not determined

12. Saturated vapor pressure (kPa,60ºC) : Not determined

13. Heat of combustion (KJ/mol) : not determined

14. Critical temperature (ºC) : Not determined

15. Critical pressure (KPa) : Not determined

16. Logarithmic value of oil-water (octanol/water) partition coefficient: not determined

17. Upper explosion limit (%,V/V) : Not determined

18. Lower explosive Limit (%,V/V) : Not determined

19 Solubility: soluble in acetone, methanol, dimethylformamide, slightly soluble in ethanol, insoluble in water