Orlistat

Orlistat name

The Chinese name is Ollista

[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate

Chinese alias orlistat | the listed company

More English nicknames

Orlistat bioactivity

Description Orlistat is a lipase inhibitor used to control obesity that acts by inhibiting the absorption of dietary fat.

Related category

Signal path > > Metabolic enzyme/protease > > Fatty acid synthase (FAS)

Research Field > > Metabolic disease

Reference literature

[1]. Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov; 35 (11) : 1103-8.

[2]. Padwal R, et al. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004; (3):CD004094.

[3]. Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15; 10(3). pii: E353.

Physicochemical properties of orlistat

Density 1.0± 0.1g /cm3

Boiling point 615.9±30.0 °C at 760 mmHg

Melting point DHS 50 C

Molecular formula C29H53NO5

Molecular weight 495.735

Flash point 326.3±24.6 °C

Accurate mass 495.392365

PSA 81.70000

LogP 8.94

Appearance solid | white

Vapor pressure 0.0±1.8 mmHg at 25°C

Refractive index 1.470

Storage conditions 2-8°C

Water soluble DMSO: 19 mg/mL