Geldanamycin NEW
Price | $20 | $10 | $1 |
Package | 1kg | 100kg | 1000kg |
Min. Order: | 1kg |
Supply Ability: | 30 tons |
Update Time: | 2023-10-09 |
Product Details
Product Name: Geldanamycin | CAS No.: 30562-34-6 |
EC-No.: 999-999-2 | Min. Order: 1kg |
Purity: 0.99 | Supply Ability: 30 tons |
Release date: 2023/10/09 |
Geldanamycin is a 1,4-benzoquinone ansamycin antitumor antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate such as hepatotoxicity, further, Jilani et al. reported that geldanamycin induces the apoptosis of erythrocytes under physiological concentrations. These side effects have led to the development of geldanamycin analogues, in particular analogues containing a derivatisation at the 17 position:
Name | Geldanamycin | EINECS | 999-999-2 |
CAS No. | 30562-34-6 | Density | 1.23 g/cm3 |
PSA | 163.48000 | LogP | 3.43750 |
Solubility | DMSO: soluble | Melting Point | 255 °C |
Formula | C29H40N2O9 | Boiling Point | 783.9 °C at 760 mmHg |
Molecular Weight | 560.645 | Flash Point | 427.9 °C |
Transport Information | N/A | Appearance | yellow to orange powder |
Appearance and properties: Yellow to orange powder
Density: 1.23g /cm3
Boiling point: 783.9ºC at 760 mmHg
Melting point: 255 °C
Flash point: 427.9ºC
Refractive index: 1.559
Storage condition: -20ºC
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$10.00/1kg |
VIP1Y
|
Wuhan Xinhao Biotechnology Co., Ltd
|
2024-03-19 | |
$0.00/25KG |
VIP4Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2023-10-19 | |
$0.00/1KG |
VIP2Y
|
Hebei Guanlang Biotechnology Co., Ltd.
|
2022-12-28 | |
$20.00/1kg |
VIP2Y
|
Hebei Duling International Trade Co. LTD
|
2022-08-17 | |
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
$1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-06-23 | |
$0.00/1KG |
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
|
2020-09-10 | ||
$1.00/1KG |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-05-07 | |
$60.00/1KG |
Hebei shuoxi biotechnology co. LTD
|
2019-11-04 | ||
$15.00/20mg |
NanJing Spring & Autumn Biological Engineering CO., LTD.
|
2019-07-17 |
- Since: 2020-05-25
- Address: Zhanggeji Village, Fengjiazhai Town, Guangzong County, Xingtai City, Hebei Province
17531190177