Valsartan/sacubitril (brand name Entresto) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotension receptor blocker in people with heart failure with reduced ejection fraction.
Side effects include angioedema, kidney problems, and low blood pressure. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi).
It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe. The wholesale cost for a year of Entresto is $4,560 per person as of 2015. Similar class generic drugs without sacubitril, such as valsartan alone, cost approximately $48 a year.

Product Name:LCZ696

CAS Number:936623-90-4

EINECS:-0

Molecular Weight:958.008

Molecular Formula:2(C24H29N5O3).2(C24H29NO5).5(H2O).6Na

Mol File:936623-90-4.mol

Solubility:≥45.05 mg/mL in DMSO; ≥11.28 mg/mL in H2O; ≥28.5 mg/mL in EtOH

PSA: 207.53000

LogP: 5.98340

COMPANY PROFILE

Hebei yanxi chemical co.,Itd is a professional research and development of the production of lead acetate,2-phenylethylamide enterprises.The key members of the company are established by local well-known entrepreneurs and professional engineers under the call and support of the party's"low-carbon environmental protectionsafety and stability"under the innovation in traditional production equipment and technology,the use of"high temperature cooling"and "plastic basin crystallization"technology,on the basis of reducing the cost of products to make the quality of products to the same industryWith the efforts of all the staff of the companywe have established many cooperative companies in Shan Dong,He Nan,Guang Dong and other places in recent decades. Under the close supervision of the quality inspection department of the company,we carry out production and sales in the way of "labeling",providing the most convenient and fastest service for users all over the countryCompanies in the"advance with The Timesand the city every day with the advancement of"under the guidance of the core ideasadhering to the"relying on scientific and technological innovationthe development of circular economy" of the enterprise purpose,established in the marketenhance strength,go the way of science and environmental sustainable developmentrelying on the national technology research and development center, increasing spending on research and development based on the domestic market, expand the international marketmanufacturing high quality productssincere service society,toward a modern, ecology, science and technologychemical enterprises of the world.