Rizatriptan benzoate
| Price | $14 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 1000kg |
| Update Time: | 2022-12-26 |
Product Details
| Product Name: Rizatriptan benzoate | CAS No.: 145202-66-0 |
| EC-No.: 604-465-6 | Min. Order: 1kg |
| Purity: 99% | Supply Ability: 1000kg |
| Release date: 2022/12/26 |
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Email: sales02@hbduling.cn
| Product Name: | Rizatriptan benzoate |
| Synonyms: | RIZATRIPTAN BENZOATE;N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE;n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate;Rizatrimptan Benzoate;Rizatrimptan;Rizatriptan monobenzoate;N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-;Acid Bixente triptans |
| CAS: | 145202-66-0 |
| MF: | C22H25N5O2 |
| MW: | 391.47 |
| EINECS: | 604-465-6 |
| Product Categories: | MK-462, Maxalt;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;API;Antimigraine;Heterocyclic Compounds;Rizatriptan;Amines |
| Mol File: | 145202-66-0.mol |
| Description | Rizatriptan was launched for the first time as Maxalt in Mexico for the acute treatment of migraine headaches with or without aura in adults. It is the third in a new generation of triptan migraine drugs to challenge the firstgeneration product Sumatriptan from Glaxo Wellcome, after Zolmitriptan (Zeneca) and Naratriptan (Glaxo Wellcome). It can be synthetically obtained by two related routes having respectively 3 and 4 steps, both starting from 1 -(4-aminobenzyl)-l,2,4-triazole. Rizatriptan is a full 5-HT1D/1B receptor agonist retaining a significant affinity at 5-HT1A sites (pIC50 = 6.4), with a low affinity for nond-HT sites. It shows craniovascufar selectivity for human isolated middle meningeal over coronary arteries ; its effect on coronary artery constriction is significantly less than that for Sumatriptan. Rizatriptan inhibits the release of neuropeptides that cause swelling of cranial blood vessels. Rizatriptan has a good oral bioavailability (64% and 47% in rats and dogs respectively). and a rapid onset of action : the headache relief in human occurs within 30 to 45 minutes of taking 20 mg. It also relieved nausea and hypersensitivity to noise (phonophobia) and light (photophobia) that are often symptoms accompanying a migraine attack. Among at least 6 metabolites identified in humans after a single oral dose (60 mg), the major urinary metabolite was the corresponding indole-3-acetic acid. Maxalt is available as a novel oral formulation of rapidly dissolving tablets or wafers that does not require liquid for ingestion. |
| Chemical Properties | Off-White Solid |
| Originator | Merck & Co (US) |
| Uses | Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist and used to treat migraine (1,2,3). It is structurally derived from tryptamine. |
| Uses | Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headac |
| Uses | A selective serotonin 5-HTID receptor agonist. Structurally derived from tryptamine |
| Brand name | Maxalt (Merck). |
| General Description | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
| Biochem/physiol Actions | Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. |
Company Profile Introduction
Hebei duling International Trade Co., Ltd. is located in Shijiazhuang, the pharmaceutical capital of China. Our company operates in various forms, including production, sales and overseas trade. At the same time, we can provide biotechnology development, consultation, exchange and promotion, technical research of biomass energy, agricultural scientific research and experimental development, etc. Our core sector is the R & D, production and sales of chemical additives and chemical intermediates.
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China- Since: 2020-09-17
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