Tianeptine Sodium Salt
| Price | $10 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | Ex 20 tons |
| Update Time: | 2022-10-11 |
Product Details
| Product Name: Tianeptine Sodium Salt | CAS No.: 30123-17-2 |
| EC-No.: 250-059-3 | Min. Order: 1kg |
| Purity: 99% | Supply Ability: Ex 20 tons |
| Release date: 2022/10/11 |
Use of Tianeptine Sodium Salt
Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo
| Name | Tianeptine sodium salt hydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo. |
|---|---|
| Related Catalog | Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease |
| Solvent | In Vitro: H2O : ≥ 235 mg/mL (512.06 mM) * "≥" means soluble, but saturation unknown. |
| Solubility | 1 mM2.1790 mL10.8949 mL21.7898 mL5 mM0.4358 mL2.1790 mL4.3580 mL10 mM0.2179 mL1.0895 mL2.1790 mL |
| Storage | Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month |
| Shipping | Room temperature in continental US; may vary elsewhere |
| SMILES | O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)[O-].[Na+] |
| References | [1]. Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2(2):115-20. [2]. Orescanin-Dusic Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7. [3]. Della FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.Behav Brain Res. 2012 Aug 1;233(2):526-35. Epub 2012 May 31. [4]. Sohn W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398. [5]. Orola L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr 30. |
| Related Molecules | Harmine | Pimavanserin | Serotonin hydrochloride | Sodium Ferulate | Thioridazine hydrochloride | Brexpiprazole | Risperidone | TG6-10-1 | Cariprazine | Quetiapine | SERTINDOLE | Alprenolol hydrochloride | B-HT 920 | Ketanserin | Palonosetron hydrochloride |
| Density | 1.38 g/cm3 |
|---|---|
| Boiling Point | 609.2ºC at 760 mmHg |
| Melting Point | 1800C |
| Molecular Formula | C21H24ClN2NaO4S |
| Molecular Weight | 458.934 |
| Flash Point | 322.2ºC |
| Exact Mass | 458.104309 |
| PSA | 97.92000 |
| LogP | 4.39460 |
| Storage condition | Desiccate at RT |
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