What is Sodium Hyaluronate?

Aug 17,2021

Sodium hyaluronic acid (Hyaluronic Acid, HA), also known as Sodium Hyaluronate, is a kind of natural macromolecule linear mucopolysaccharide formed by repeatedly connecting D-glucuronic acid and N-acetylglucosamine as disaccharide units. It exists widely In animal tissues and body fluids, such as joint fluid, eye vitreous, umbilical cord, skin, etc. Due to its unique structure, sodium hyaluronate has good viscoelasticity and excellent water retention, and has important physiological and biological functions, and has good histocompatibility and non-immunogenicity. Therefore, it is clinically It has a wide range of applications. For example, when sodium hyaluronate is used in ophthalmic surgery, it can protect the eye tissue; treat osteoarthritis and rheumatoid arthritis; as a soft tissue filler, it can correct tear groove deformity and lip augmentation , Earlobe, etc.; can also be used as a drug carrier.

Clinical use

Sodium hyaluronate is a polymer mucopolysaccharide with strong viscoelasticity and osmotic pressure. It is a physiologically active substance of the human body. It is currently widely used in various tissues of the human body. It is not only the main component of joint synovial fluid, but also An important component of cartilage matrix. Sodium hyaluronate is placed in the uterine cavity and it can be absorbed within 2 hours, so it can quickly and effectively prevent uterine adhesions. The main mechanism of sodium hyaluronate in preventing intrauterine adhesions in hysteroscopic surgery is that it has a strong lubricating function, which can reduce friction, reduce the production of fibrin, promote rapid wound healing, relieve local inflammation, and control bleeding. A chemical scaffold can be formed in the uterine cavity, and at the same time it can promote the growth and differentiation of serosal cells, thereby having the effect of physiologically repairing the wounded serosal membrane, so it has a good role in preventing adhesions. 

In summary, sodium hyaluronate has a positive effect on preventing the recurrence of intrauterine adhesions after hysteroscopic surgery, can improve the clinical efficacy, and is worthy of clinical application.

Pharmacology 

Mechanism of action: Sodium hyaluronate can be combined with fibronectin, which promotes the connection and extension of epithelial cells. In addition, since it can hold many water molecules in its molecule, it has excellent water retention. Promote the healing effect of corneal trauma (rabbit): Use the surgical method to peel the corneal epithelium to the basement membrane to make rabbit corneal epithelial trauma model. When 0.1%-0.5% sodium hyaluronate is used for eye drops, it will be separated from the matrix after 24 hours. Compared with the eye drop group, it has a significant effect on promoting wound healing. Promote corneal epithelial extension (in vitro>): For the cultured tissue of isolated rabbit corneal sheet, sodium hyaluronate can promote the extension of corneal epithelial cell layer compared with the control group. Water-promoting effect (in vitro): When 0.1%-1.0% sodium hyaluronate solution is dropped on agar medium, sodium hyaluronate inhibits the weight loss of agar medium caused by water evaporation in a concentration-dependent manner. The following eye drops toxicity test was performed on rabbits, and no eye irritation and toxicity were seen.

Indications

Corneal and conjunctival epithelial injury accompanied by the following diseases: Endogenous diseases such as sjogren's syndrome, Stevens-Johnson syndrome, dryeye syndrome (dryeye syndrome), etc.; after surgery, drug-induced , Trauma, wearing contact lenses and other external diseases.

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Sodium hyaluronate manufacturers

  • Sodium hyaluronate
  • 9067-32-7 Sodium hyaluronate
  • $10.00 / 1kg
  • 2024-03-29
  • CAS:9067-32-7
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 5000 Metric Ton/Month
  • Sodium Hyaluronate
  • 9067-32-7 Sodium Hyaluronate
  • $23.00 / 1KG
  • 2024-03-29
  • CAS:9067-32-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5000KG
  • Sodium Hyaluronate
  • 9067-32-7 Sodium Hyaluronate
  • $0.00 / 1kg
  • 2024-03-29
  • CAS:9067-32-7
  • Min. Order: 0.10000000149011612kg
  • Purity: 99%
  • Supply Ability: 20tons