Chemical Safety Data Sheet MSDS / SDS

4-Dimethylaminopyridine

Revision Date:2024-04-06Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 4-Dimethylaminopyridine
CBnumber: CB9852862
CAS: 1122-58-3
EINECS Number: 214-353-5
Synonyms: DMAP,4-dimethylaminopyridine

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P262 Do not get in eyes, on skin, or on clothing.

P264 Wash hands thoroughly after handling.

P264 Wash skin thouroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313 IF eye irritation persists: Get medical advice/attention.

P370+P378 In case of fire: Use … for extinction.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/container to..…

Hazard statements

H225 Highly Flammable liquid and vapour

H301 Toxic if swalloed

H302 Harmful if swallowed

H310 Fatal in contact with skin

H311 Toxic in contact with skin

H314 Causes severe skin burns and eye damage

H315 Causes skin irritation

H318 Causes serious eye damage

H319 Causes serious eye irritation

H335 May cause respiratory irritation

H336 May cause drowsiness or dizziness

H351 Suspected of causing cancer

H402 Harmful to aquatic life

SECTION 3: Composition/information on ingredients

Substance

Product name: 4-Dimethylaminopyridine
Synonyms: DMAP,4-dimethylaminopyridine
CAS: 1122-58-3
EC number: 214-353-5
MF: C7H10N2
MW: 122.17

SECTION 4: First aid measures

Description of first aid measures

General advice

First aider needs to protect himself. Show this material safety data sheet to the doctor in

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Body Protection

protective clothing

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type: Filter type P3

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearance solid
OdourNo data available
Odour ThresholdNo data available d) pH 10,23 at 0,1 g/l at 22 °C Melting point/freezing point Initial boiling point and boiling range Melting point/range: 108 - 110 °C - lit. 162 °C Flash point 124 °C - DIN 51758 Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available No data available Vapour pressure No data available Vapour density No data available Relative density 0,96 at 120 °C Water solubility No data available Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature No data available No data available No data available Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available Explosive properties No data available Oxidizing properties No data available
Melting point/freezing pointMelting point/range: 108 - 110 °C - lit.
Initial boiling point and boiling range 162 °C
Flash point124 °C - DIN 51758
Evaporation rate110 °C
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsNo data available
Vapour pressure No data available
Vapour density 0.169 hPa at 20 °C
Relative density0,96 at 120 °C
Water solubilityNo data available
Partition coefficient: n-octanol/watermethanol: 50 mg/mL, clear
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

Forms explosive mixtures with air on intense heating.

A range from approx. 15 Kelvin below the flash point is to be rated as critical.

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Violent reactions possible with:

Strong oxidizing agents acids

Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!

Conditions to avoid

Strong heating.

Incompatible materials

no information available

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male - 140 mg/kg (US-EPA)
Symptoms: Nausea, Vomiting, Diarrhea LC50 Inhalation - Rat - 4 h - 0,53 mg/l (US-EPA)
Symptoms: mucosal irritations, Headache, Nausea, Drowsiness, somnolence, After a latency period:, Inhalation may lead to the formation of oedemas in the respiratory tract. LD50 Dermal - Rabbit - male and female - 90 mg/kg
Remarks:
(ECHA)

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

Eyes - Rabbit Result: Corrosive Remarks:
(ECHA)

Respiratory or skin sensitization

Buehler Test - Guinea pig Result: negative
(OECD Test Guideline 406)

Germ cell mutagenicity

Ames test
Escherichia coli/Salmonella typhimurium Result: negative
In vitro mammalian cell gene mutation test mouse lymphoma cells
Result: negative Remarks:
(ECHA)

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

Causes damage to organs. - Nervous system Acute oral toxicity - Nausea, Vomiting, Diarrhea
Acute inhalation toxicity - mucosal irritations, Headache, Nausea, Drowsiness, somnolence, After a latency period:, Inhalation may lead to the formation of oedemas in the respiratory tract.

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Toxicity

LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg

SECTION 12: Ecological information

Toxicity

Toxicity to fish

semi-static test LC50 - Danio rerio (zebra fish) - 11,6 mg/l - 96 h (OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test LC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae

static test ErC50 - Pseudokirchneriella subcapitata - 4,22 mg/l - 72 h (OECD Test Guideline 201)

Toxicity to bacteria

static test IC50 - Tetrahymena pyriformis - 527,09 mg/l - 60 h Remarks: (ECHA)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 0 % - Not readily biodegradable. (Closed Bottle test)

Remarks: (ECHA)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14: Transport information

UN number

ADR/RID: 2811 IMDG: 2811 IATA: 2811

UN proper shipping name

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (N,N-dimethylpyridin-4-amine) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (N,N-dimethylpyridin-4-amine) IATA: Toxic solid, organic, n.o.s. (N,N-dimethylpyridin-4-amine)

Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

EC Inventory:Listed.

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.