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ChemicalBook >> CAS DataBase List >> Lorlatinib (PF-06463922)

Lorlatinib (PF-06463922)

Lorlatinib (PF-06463922) price.
  • $37 - $1335
  • Product name: Lorlatinib (PF-06463922)
  • CAS: 1454846-35-5
  • MF: C21H19FN6O2
  • MW: 406.41
  • EINECS:813-704-5
  • MDL Number:
  • Synonyms:(10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile;Lorlatinib,PF-06463922;PF-06463922, Lorlatinib;(R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile;Lorlatinib(PF0643922);High Purity API Lorlatinib;Anaplastic lymphoma kinase (ALK);Lorlatinib Powder
Price29 Properties Safety Information Description
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 5mg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging5mg
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging10mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging25mg
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging100mg
  • Price$359
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging250mg
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging5mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging10mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging25mg
  • Price$106
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging50mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging100mg
  • Price$222
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging250mg
  • Price$445
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging1g
  • Price$1335
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4882
  • Product descriptionPF-06463922
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4882
  • Product descriptionPF-06463922
  • Packaging10mM(in 1mL DMSO)
  • Price$83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4882
  • Product descriptionPF-06463922
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2600
  • Product descriptionPF06463922-Lorlatinib 99%
  • Packaging25mg
  • Price$423.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 5mg $136 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 10mg $176 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 25mg $254 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 100mg $359 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 250mg $660 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 5mg $62 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 10mg $87 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 25mg $106 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 50mg $139 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 100mg $222 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 250mg $445 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 1g $1335 2021-12-16 Buy
ApexBio Technology B4882 PF-06463922 5mg $65 2021-12-16 Buy
ApexBio Technology B4882 PF-06463922 10mM(in 1mL DMSO) $83 2021-12-16 Buy
ApexBio Technology B4882 PF-06463922 25mg $240 2021-12-16 Buy
Axon Medchem Axon2600 PF06463922-Lorlatinib 99% 25mg $423.5 2021-12-16 Buy
Next Last

Properties

Melting point :184-187°C
Boiling point :675.0±55.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Solid
pka :6.05±0.40(Predicted)
color :White to Off-White
Stability :Hygroscopic
InChI :InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
InChIKey :IIXWYSCJSQVBQM-LLVKDONJSA-N
SMILES :[C@@H]1(C)C2=CC(F)=CC=C2C(=O)N(C)CC2=NN(C)C(C#N)=C2C2C=C(C(N)=NC=2)O1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.

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Suppliers and manufacturers

Henan Fengda Chemical Co., Ltd
Lorlatinib (PF-06463922)
$1.00 /100KG
Lorlatinib (PF-06463922) CAS:1454846-35-5
Zhengzhou Anhuida Chemical Co., Ltd
Capot Chemical Co.,Ltd.
Nanjing Gold Pharmaceutical Technology Co. Ltd.
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Nanjing Finetech Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
TianYuan Pharmaceutical CO.,LTD
BOC Sciences