MP-A08
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- $34 - $2707
- Product name: MP-A08
- CAS: 219832-49-2
- MF: C27H25N3O4S2
- MW: 519.64
- EINECS:
- MDL Number:
- Synonyms:MP-A08;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide , MP-A08;MP-A08, 10 mM in DMSO;MP-A08 ，E0482
43 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250MG
- 1G
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide ≥98%
- Packaging1mg
- Price$37
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- Packaging5mg
- Price$47
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- Packaging10mg
- Price$63
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- Packaging25mg
- Price$103
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- Packaging50mg
- Price$175
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- Packaging100mg
- Price$295
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4X
- Product description4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- Packaging200mg
- Price$404
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX186214
- Product descriptionMP-A08 95%
- Packaging100MG
- Price$430
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX186214
- Product descriptionMP-A08 95%
- Packaging250MG
- Price$590
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX186214
- Product descriptionMP-A08 95%
- Packaging1G
- Price$1230
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2209CC
- Product description4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide
- Packaging25mg
- Price$538
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-19794
- Product descriptionMP-A08 98.0%
- Packaging25mg
- Price$171
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19794
- Product descriptionMP-A08 98.0%
- Packaging100mg
- Price$485
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19794
- Product descriptionMP-A08 98.0%
- Packaging50mg
- Price$276
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19794
- Product descriptionMP-A08 98.0%
- Packaging10mg
- Price$86
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19794
- Product descriptionMP-A08 98.0%
- Packaging5mg
- Price$53
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide ≥98% | 1mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide | 5mg | $47 | 2026-05-28 | Buy |
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide | 10mg | $63 | 2026-05-28 | Buy |
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide | 25mg | $103 | 2026-05-28 | Buy |
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide | 50mg | $175 | 2026-05-28 | Buy |
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide | 100mg | $295 | 2026-05-28 | Buy |
| aablocks | AA00BF4X | 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide | 200mg | $404 | 2026-05-28 | Buy |
| ACHEMBLOCK | X186214 | MP-A08 95% | 100MG | $430 | 2026-05-27 | Buy |
| ACHEMBLOCK | X186214 | MP-A08 95% | 250MG | $590 | 2026-05-27 | Buy |
| ACHEMBLOCK | X186214 | MP-A08 95% | 1G | $1230 | 2026-05-27 | Buy |
| AK Scientific | 2209CC | 4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide | 25mg | $538 | 2021-12-16 | Buy |
| Arctom | HY-19794 | MP-A08 98.0% | 25mg | $171 | 2026-05-26 | Buy |
| Arctom | HY-19794 | MP-A08 98.0% | 100mg | $485 | 2026-05-26 | Buy |
| Arctom | HY-19794 | MP-A08 98.0% | 50mg | $276 | 2026-05-26 | Buy |
| Arctom | HY-19794 | MP-A08 98.0% | 10mg | $86 | 2026-05-26 | Buy |
| Arctom | HY-19794 | MP-A08 98.0% | 5mg | $53 | 2026-05-26 | Buy |
Properties
Boiling point :717.1±70.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
solubility :DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
form :A crystalline solid
pka :7.88±0.10(Predicted)
color :Light yellow to yellow
Density :1.28±0.1 g/cm3(Predicted)
solubility :DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
form :A crystalline solid
pka :7.88±0.10(Predicted)
color :Light yellow to yellow
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (Kis = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.Suppliers and manufacturers
MedChemexpress LLC
Sichuan Wei Keqi Biological Technology Co., Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
Beijing Solarbio Science & Tecnology Co., Ltd.
Amadis Chemical Company Limited
MQ (shanghai) Pharmaceuticals Co., Ltd.
Musechem
Fan De(Beijing) Biotechnology Co., Ltd.