NODULARIN
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- $138 - $2200
- Product name: NODULARIN
- CAS: 118399-22-7
- MF: C41H60N8O10
- MW: 824.96
- EINECS:621-437-9
- MDL Number:MFCD16659855
- Synonyms:tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth ;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl) ;NODULARIN;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE;Nodularin, Nodularia spumigena;1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl);Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
7 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 100μg
- 100ug
- 250μg
- 1MG
- 1ml
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCCH0006050
- Product descriptionCYCLO(3S-AMINO-9S-METHOXY-2S,6E,8S-TRIMETHYL-10-PHENYL-4,6-DECADIENOYL-D-GAMMA-GLUTAMYL-(2Z)-2-(METHYLAMINO)-2-BUTENOYL-(3S)-3-METHYL-D-BETA-ASPARTYL-L-ARGINYL) 95.00%
- Packaging1MG
- Price$1250.55
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10007190
- Product descriptionNodularin ≥95%
- Packaging100μg
- Price$138
- Updated2024-03-01
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number47934
- Product descriptionNodularin
- Packaging1mg
- Price$2200
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number32539
- Product descriptionNodularin solution 10μg/mL in methanol, analytical standard
- Packaging1ml
- Price$590
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberN5148
- Product descriptionNodularin cyanotoxin
- Packaging250μg
- Price$638
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberN634260
- Product descriptionNodularin
- Packaging1mg
- Price$1320
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number170023
- Product descriptionNodularin
- Packaging100ug
- Price$325
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CCH0006050 | CYCLO(3S-AMINO-9S-METHOXY-2S,6E,8S-TRIMETHYL-10-PHENYL-4,6-DECADIENOYL-D-GAMMA-GLUTAMYL-(2Z)-2-(METHYLAMINO)-2-BUTENOYL-(3S)-3-METHYL-D-BETA-ASPARTYL-L-ARGINYL) 95.00% | 1MG | $1250.55 | 2021-12-16 | Buy |
| Cayman Chemical | 10007190 | Nodularin ≥95% | 100μg | $138 | 2024-03-01 | Buy |
| Medical Isotopes, Inc. | 47934 | Nodularin | 1mg | $2200 | 2021-12-16 | Buy |
| Sigma-Aldrich | 32539 | Nodularin solution 10μg/mL in methanol, analytical standard | 1ml | $590 | 2024-03-01 | Buy |
| Sigma-Aldrich | N5148 | Nodularin cyanotoxin | 250μg | $638 | 2024-03-01 | Buy |
| TRC | N634260 | Nodularin | 1mg | $1320 | 2021-12-16 | Buy |
| Usbiological | 170023 | Nodularin | 100ug | $325 | 2021-12-16 | Buy |
Properties
Density :1.29±0.1 g/cm3(Predicted)
Flash point :11℃
storage temp. :−20°C
solubility :methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form :Dry residue containing traces of monobasic potassium phosphate.
pka :3.39±0.70(Predicted)
IARC :3 (Vol. 94) 2010
EPA Substance Registry System :Nodularin (118399-22-7)
Flash point :11℃
storage temp. :−20°C
solubility :methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form :Dry residue containing traces of monobasic potassium phosphate.
pka :3.39±0.70(Predicted)
IARC :3 (Vol. 94) 2010
EPA Substance Registry System :Nodularin (118399-22-7)
Safety Information
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Description
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.Related product price
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