Ro 3306
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- $20 - $2691.1
- Product name: Ro 3306
- CAS: 872573-93-8
- MF: C18H13N3OS2
- MW: 351.45
- EINECS:
- MDL Number:MFCD17392573
- Synonyms:Ro 3306;2-[[(Thiophen-2-yl)methyl]amino]-5-[1-(quinolin-6-yl)meth-(Z)-ylidene]thiazol-4-one;(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one;(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one;5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone;RO3306;RO 3306;4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-;(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one
39 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Tocris
- Usbiological
Package
- 10mg
- 2x5mg
- 10
- 1mg
- 5mg
- 25mg
- 50
- 50mg
- 2x25mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3515-M001
- Product descriptionRO-3306 ≥95%(NMR)
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3515-M005
- Product descriptionRO-3306 ≥95%(NMR)
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4010AH
- Product description5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
- Packaging50mg
- Price$343
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging1mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging5mg
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging10mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging50mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging100mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging250mg
- Price$206
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA138869
- Product descriptionRo3306 98+%
- Packaging1g
- Price$514
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010297
- Product description5-(6-QUINOLINYLMETHYLENE)-2-[(2-THIENYLMETHYL)AMINO]-4-(5H)-THIAZOLONE 95.00%
- Packaging1MG
- Price$140.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010297
- Product description5-(6-QUINOLINYLMETHYLENE)-2-[(2-THIENYLMETHYL)AMINO]-4-(5H)-THIAZOLONE 95.00%
- Packaging10MG
- Price$794.36
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8885
- Product descriptionRo3306
- Packaging10mM(in 1mL DMSO)
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8885
- Product descriptionRo3306
- Packaging50mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1530
- Product descriptionRO3306 99%
- Packaging2x5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1530
- Product descriptionRO3306 99%
- Packaging25mg
- Price$286
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3515-M001 | RO-3306 ≥95%(NMR) | 1mg | $25 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3515-M005 | RO-3306 ≥95%(NMR) | 5mg | $75 | 2021-12-16 | Buy |
| AK Scientific | 4010AH | 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone | 50mg | $343 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 1mg | $20 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 5mg | $34 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 10mg | $44 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 50mg | $75 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 100mg | $138 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 250mg | $206 | 2021-12-16 | Buy |
| Ambeed | A138869 | Ro3306 98+% | 1g | $514 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010297 | 5-(6-QUINOLINYLMETHYLENE)-2-[(2-THIENYLMETHYL)AMINO]-4-(5H)-THIAZOLONE 95.00% | 1MG | $140.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010297 | 5-(6-QUINOLINYLMETHYLENE)-2-[(2-THIENYLMETHYL)AMINO]-4-(5H)-THIAZOLONE 95.00% | 10MG | $794.36 | 2021-12-16 | Buy |
| ApexBio Technology | A8885 | Ro3306 | 10mM(in 1mL DMSO) | $75 | 2021-12-16 | Buy |
| ApexBio Technology | A8885 | Ro3306 | 50mg | $280 | 2021-12-16 | Buy |
| Axon Medchem | Axon1530 | RO3306 99% | 2x5mg | $132 | 2021-12-16 | Buy |
| Axon Medchem | Axon1530 | RO3306 99% | 25mg | $286 | 2021-12-16 | Buy |
Properties
Boiling point :569.1±60.0 °C(Predicted)
Density :1.41
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :3.99±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.41
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :3.99±0.10(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling. It also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and serum- and glucocorticoid-induce kinase (Ki = 497 nM) but not Cdk4. Through its effects on Cdk1, Ro 3306 reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization without the use of microtubule poisons. Prolonged treatment of cells with Ro 3306 induces apoptosis and this can be augmented in acute myeloid leukemia cells by stimulating p53 activity with nutlin-3.More related product prices
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4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- CAS:872573-93-8
4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- CAS:872573-93-8