YM-53601
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- $207 - $1631
- Product name: YM-53601
- CAS: 182959-33-7
- MF: C21H21FN2O.ClH
- MW: 372.869
- EINECS:
- MDL Number:MFCD06411577
- Synonyms:2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole:hydrochloride;2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride;YM-53601 Exclusive;9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1)
4 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
Package
- 500μg
- 1mg
- 5MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005643
- Product description2-((2E)-2-(1-AZABICYCLO(2.2.2)OCT-3-YLIDENE)-2-FLUOROETHOXY)-9H-CARBAZOLE, MONOHYDROCHLORIDE 95.00%
- Packaging5MG
- Price$657
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18113
- Product descriptionYM-53601 ≥98%
- Packaging500μg
- Price$207
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18113
- Product descriptionYM-53601 ≥98%
- Packaging1mg
- Price$388
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18113
- Product descriptionYM-53601 ≥98%
- Packaging5mg
- Price$1631
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0005643 | 2-((2E)-2-(1-AZABICYCLO(2.2.2)OCT-3-YLIDENE)-2-FLUOROETHOXY)-9H-CARBAZOLE, MONOHYDROCHLORIDE 95.00% | 5MG | $657 | 2021-12-16 | Buy |
| Cayman Chemical | 18113 | YM-53601 ≥98% | 500μg | $207 | 2024-03-01 | Buy |
| Cayman Chemical | 18113 | YM-53601 ≥98% | 1mg | $388 | 2024-03-01 | Buy |
| Cayman Chemical | 18113 | YM-53601 ≥98% | 5mg | $1631 | 2024-03-01 | Buy |
Properties
Melting point :236.5-237.2 °C
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 2 mg/ml
form :A crystalline solid
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 2 mg/ml
form :A crystalline solid
Safety Information
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Description
Squalene synthase catalyzes the dimerization of two farnesyl pyrophosphate molecules to form the key cholesterol precursor, squalene. YM-53601 inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells with IC50 values of 90 and 79 nM, respectively. Cholesterol biosynthesis is inhibited in rats with an ED50 value of 32 mg/kg YM-53601, causing a reduction in both cholesterol and triglyceride levels in plasma. Cholesterol-reducing HMG-CoA reductase inhibitors, which have little effect on plasma triglyceride levels, are often paired with fibrates, which can have adverse effects, to treat hyperlipidemia. The lipid-lowering properties of compounds such as YM-53601 make squalene synthase inhibition an attractive alternative to the combination HMG-CoA reductase inhibitor/fibrate therapy.More related product prices
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