3-氨基丙烷磺酸
中文名称 | 3-氨基丙烷磺酸 |
---|---|
中文同义词 | 3- 氨基-1-丙磺酸;3-氨基-1-丙烷磺酸;高牛黄酸;3-氨基丙烷磺酸;3-氨基丙烷-1-磺酸;高牛磺酸;阿坎酸钙相关物质A;高牛磺酸(3-氨基丙磺酸) |
英文名称 | 3-Amino-1-propanesulfonic acid |
英文同义词 | aminopropanesulfonicacid,3-aminopropanesulfonicacid;3-AMINO-1-PROPANESULFONIC ACID;3-AMINOPROPANESULFONIC ACID;3 APS;3-aminopropane-1-sulphonic acid;TRAMIPROSATE;3-Aminopropiosulfonic Acid;3-Sulfopropylamine |
CAS号 | 3687-18-1 |
分子式 | C3H9NO3S |
分子量 | 139.17 |
EINECS号 | 222-977-4 |
相关类别 | 小分子抑制剂,天然产物;磺酸;亚磺酸盐;小分子抑制剂;磺酸/亚磺酸盐;有机砌块;中间体;Metal Isotopes;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfonic/Sulfinic Acids;Inhibitors;医药化工类;原料;化工原料;有机化工原料;化工中间体;有机中间体;医药原料中间体;医药原料;医用原料;Pharmaceutical Raw Materials;Sulfur Compounds;API |
Mol文件 | 3687-18-1.mol |
结构式 |
3-氨基丙烷磺酸 性质
熔点 | 293 °C (dec.)(lit.) |
---|---|
密度 | 1.202 (estimate) |
折射率 | 1.5130 (estimate) |
储存条件 | 2-8°C |
溶解度 | 可微溶于水 |
形态 | 结晶粉末 |
酸度系数(pKa) | 1.06±0.50(Predicted) |
颜色 | 白色至略带蓝色 |
LogP | -4.555 |
CAS 数据库 | 3687-18-1(CAS DataBase Reference) |
Target | Value |
GABA receptor
() |
Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane.
Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery.
Animal Model: | Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO) |
Dosage: | 50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg |
Administration: | Intraperitoneal injection; once |
Result: | Dose-dependently reduced the infarct volume after MCAO. |
提供商 | 语言 |
---|---|
英文
|
|
英文
|
|
英文
|