白术内酯 I
中文名称 | 白术内酯 I |
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中文同义词 | 白术内酯 I;白术油;白术内酯I(苍术内酯I);白术内酯Ⅰ(标准品);苍术内酯I;ATRACTYLENOLIDE I 白术内酯Ⅰ;白术内酯Ⅰ/苍术内酯I;ATRACTYLENOLIDE I 白术内酯Ⅰ 标准品 |
英文名称 | Atractylenolide-1 |
英文同义词 | ATRACTYLENOLIDE-1;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one;Eudesma-4(15),7(11),8-trien-12-olide;8,9-Dehydroasterolide;(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;Atractylenolide Ⅰ;Atractylenolide I, >99%;Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)- |
CAS号 | 73069-13-3 |
分子式 | C15H18O2 |
分子量 | 230.3 |
EINECS号 | |
相关类别 | 中药对照品;标准品;对照品,标准品;植物提取物;对照品;植提标准品;标准物质;可定制;天然植物精油;单方精油;分析试剂标准品;香精香料;香精香料;标准品-中药标准品;倍半萜;标准品 -中药标准品;标准品,对照品;天然全草精油 |
Mol文件 | 73069-13-3.mol |
结构式 |
白术内酯 I 性质
熔点 | 121-123 °C(Solv: ligroine (8032-32-4)) |
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沸点 | 405.0±44.0 °C(Predicted) |
密度 | 1.12 |
闪点 | 170℃ |
储存条件 | 2-8°C |
溶解度 | 在甲醇中可溶1mg/mL,透明,无色 |
形态 | 粉末 |
颜色 | 白色 |
InChIKey | ZTVSGQPHMUYCRS-SWLSCSKDSA-N |
JAK2, STAT3, TLR4
Atractylenolide I (40, 60, 80, 100, 120, 150 μM) dose- and time-dependently reduces the cell viability in human A375 melanoma cells after treatment for 24, 48 and 72 hours. Atractylenolide I (50 and 100 μM) induces apoptosis of A375 cells in a dose-dependent manner at 48 h of treatment. Atractylenolide I (100 μM) significantly reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, without effect on total JAK2 and STAT3. Furthermore, Atractylenolide I inhibits the mRNA expression of STAT3-targeted genes, including Bcl-xL, MMP-2 and MMP-9. Atractylenolide I (up to 100 μM) shows no toxicity in normal cells. Atractylenolide I (25, 50 μM) decreases the Ox-LDL induced TNF-α, IL-6 and NO production in VSMCs. Atractylenolide I (12.5, 25 or 50 μM) significantly reduces the level of MCP-1 and inhibits Ox-LDL-induced VSMCs proliferation and migration. Atractylenolide I (25, 50 μM) inhibits positive staining of foam cells, and also significantly decreases lipid accumulation. Atractylenolide I (50 μM) suppresses p38MAPK and NF-κB p65 expression in VSMCs stimulated by Ox-LDL. Atractylenolide I (1, 10, 100 μM) downregulates paclitaxel-induced expression of VEGF and survivin via MyD88-dependent TLR4 signaling in EOC cells.
Atractylenolide I (5, 10 or 20 mg/kg, p.o.) restores the decreased body weight in mice subjected to chronic unpredictable mild stress (CUMS). Atractylenolide I alleviates CUMS-induced depressive-like behavior, attenuates CUMS-induced imbalances in hippocampal neurotransmitter levels and reduces CUMS-induced increases in hippocampal pro-inflammatory cytokine levels and in the NLRP3 inflammasome in the hippocampi of mice.
药理药效:白术内酯Ⅰ能促进胃肠道消化吸收功能,是白术键脾的有效成分之-.具有抗炎、抗肿瘤作用,该成分还具有调节胃肠道功能和促进营养物质吸收的功能。
安全信息
WGK Germany | 3 |
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