地榆皂苷Ⅱ
中文名称 | 地榆皂苷Ⅱ |
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中文同义词 | 地榆皂苷 II;地榆皂苷II(标准品);地榆甙II;地榆皂苷LL;地榆皂苷II对照品,;地榆皂苷II、地榆苷Ⅱ;坡模酸-3-O-Α-L-吡喃阿拉伯糖苷;地榆皂苷Ⅱ |
英文名称 | Ziyuglycoside II |
英文同义词 | Ziyuglycoside II;(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Zigu-glucoside II;Gouguside 1;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-;Ziyuglycoside;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oicaci |
CAS号 | 35286-59-0 |
分子式 | C35H56O8 |
分子量 | 604.83 |
EINECS号 | 233-305-4 |
相关类别 | 中药对照品;标准品;植物提取物;对照品;植提标准品;chemical reagent;pharmaceutical intermediate;phytochemical;分析试剂标准品;标准品-中药标准品;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;三萜;标准品,对照品;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 35286-59-0.mol |
结构式 |
地榆皂苷Ⅱ 性质
熔点 | 260-263℃ |
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沸点 | 716.2±60.0 °C(Predicted) |
密度 | 1.25 |
储存条件 | -20°C, protect from light |
溶解度 | 溶于DMSO和甲醇; |
酸度系数(pKa) | 4.47±0.70(Predicted) |
形态 | 粉末 |
颜色 | 白色至米白色 |
水溶解性 | insoluble in water |
Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC
50
of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
Cell Viability Assay
Cell Line: | MDA-MB-435 cells |
Concentration: | 10, 20, 30, 40, 50, 60 μM |
Incubation Time: | 24 hours and 48 hours |
Result: | The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. |
Cell Cycle Analysis
Cell Line: | MDA-MB-435 cells |
Concentration: | 5, 10, 25 μM |
Incubation Time: | 24 hours |
Result: | Induced G0/G1 and S phase arrest. |
Apoptosis Analysis
Cell Line: | MDA-MB-435 cells |
Concentration: | 5, 10, 25 μM |
Incubation Time: | 24 hours |
Result: | The apoptotic rate was significantly increased in comparison to that of the control. |
Western Blot Analysis
Cell Line: | MDA-MB-435 cells |
Concentration: | 5, 10, 25 μM |
Incubation Time: | 24 hours |
Result: | Treatment resulted in increased expressions of both p53 and p21. |
药理药效:具有一定的酪氨酸酶抑制作用,保肝利胆效果。
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 5mg | 550元 |
2024/08/19 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 10mg | 950元 |