ChemicalBook CAS DataBase List 1-(2-N-Boc-Aminoethyl)piperazine

1-(2-N-Boc-Aminoethyl)piperazine synthesis

9synthesis methods

Product Name:1-(2-N-Boc-Aminoethyl)piperazine
CAS Number:140447-78-5
Molecular formula:C11H23N3O2
Molecular Weight:229.32

1-CBZ-4-(2-N-BOC-AMINO-ETHYL)-PIPERAZINE

500013-42-3
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140447-78-5
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Yield:140447-78-5 97%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol for 2 h;

Steps:

22.D 22D: tert-Butyl 2-(1-piperazinyl)ethylcarbamate
Hydrogen was passed through a degassed solution of benzyl 4-(2-(tert-butyloxycarbonylamino)ethyl)piperazine-1-carboxylate (2.60 g, 7.16 mmol) in methanol (50 ml) containing 10% palladium on carbon (500 mg) for 2 h. The reaction mixture was filtered through Celite and the filtrate was concentratedin vacuo to give a yellow gum identified as tert-butyl 2-(1-piperazinyl)ethylcarbamate (1.60 g, 97%).

References:

Ferring B.V. EP1449844, 2004, A1 Location in patent:Page 34

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