ChemicalBook CAS DataBase List 1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE

1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE synthesis

8synthesis methods

Product Name:1-(5-CHLORO-1H-INDOL-3-YL)ETHANONE
CAS Number:51843-24-4
Molecular formula:C10H8ClNO
Molecular Weight:193.63

17422-32-1

108-24-7

51843-24-4

The general procedure for the synthesis of 5-chloro-3-indoleacetophenone from 5-chloroindole and ethanoic anhydride: 1 mmol of 5-chloroindole, 1 mmol of ethanoic anhydride, 0.01 mmol of metal salt catalyst of trifluoromethanesulfonic acid, and 1 mmol of ionic liquid were sequentially added to a 10 mL glass reaction tube suitable for single mode microwave reaction. Subsequently, the reaction tube was sealed with a polytetrafluoroethylene cap and placed in a single-mode microwave reactor, and the microwave radiation reaction was carried out under different temperature and time conditions to optimize the reaction conditions. After completion of the reaction, the reaction tube was cooled to room temperature and the reaction mixture was extracted with ether (5 × 10 mL). The ether layer was separated and washed with deionized water (2 × 10 mL), saturated aqueous sodium bicarbonate solution (2 × 20 mL) and saturated saline (2 × 10 mL) sequentially. The organic phase was dried over anhydrous magnesium sulfate and filtered, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, n-hexane/ethyl acetate, gradient elution ratio from 10:0 to 8:2) to obtain the target product 5-chloro-3-indoleacetophenone, and the isolated yield was calculated.

17422-32-1 Synthesis

17422-32-1
383 suppliers
$6.00/1g

75-36-5 Synthesis

75-36-5
592 suppliers
$17.92/100G

51843-24-4
76 suppliers
$40.00/250mg

Yield:51843-24-4 91%

Reaction Conditions:

with diethylaluminium chloride in dichloromethane at 0; for 2 h;

References:

Barreca, Maria Letizia;Ferro, Stefania;Rao, Angela;De Luca, Laura;Zappalà, Maria;Monforte, Anna-Maria;Debyser, Zeger;Witvrouw, Myriam;Chimirri, Alba [Journal of Medicinal Chemistry,2005,vol. 48,# 22,p. 7084 - 7088]

17422-32-1 Synthesis

17422-32-1
383 suppliers
$6.00/1g

108-24-7
0 suppliers
$14.00/250ML

51843-24-4
76 suppliers
$40.00/250mg

References

127-19-5 Synthesis