1-amino-2-naphthonitrile synthesis
- Product Name:1-amino-2-naphthonitrile
- CAS Number:3100-67-2
- Molecular formula:C11H8N2
- Molecular Weight:168.19
Yield: 75%
Reaction Conditions:
with potassium cyanide;potassium hydroxide in N,N-dimethyl-formamide at 60;
Steps:
10-(2) Synthesis of 10-(2) 10-b
1-nitronaphthalene (97 g, 0.56 mol), methyl cyanoacetate (166.5 g, 1.68 mol), potassium cyanide (40.1 g, 0.62 mol), and potassium hydroxide (62.9 g, 1.12 mol) were added and stirred.Then, 970 mL of dimethylformamide was added and stirred at 60°C overnight.After removing the solvent by concentrating under reduced pressure at room temperature, 500 mL of a 10% aqueous sodium hydroxide solution was added and refluxed for about 1 hour.After extraction with ethyl acetate, separation by column chromatography and recrystallization from toluene and heptane to give the target product 50.8 g (75% yield).
References:
SFC Ltd.;Park Ji-hui;Sim So-yeong;Ryu Se-jin KR102191780, 2020, B1 Location in patent:Paragraph 0541; 0548-0553
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