ChemicalBook CAS DataBase List 1-Aminocyclopropanecarboxylic acid

1-Aminocyclopropanecarboxylic acid synthesis

8synthesis methods

Product Name:1-Aminocyclopropanecarboxylic acid
CAS Number:22059-21-8
Molecular formula:C4H7NO2
Molecular Weight:101.1

1-Aminocyclopropanecarboxylic acid is a cyclic amino acid, also known as ACC, a non-protein amino acid widely found in pears, apples and other fruits. The famous German organic chemist Schoenkopf used ethyl cyanoacetate and 1,2-dibromoethane to form a three-membered ring with NaH in a nitrogen environment, and then reacted with hydrochloric acid to prepare 1-aminocyclopropanecarboxylate hydrochloride .

68781-13-5 Synthesis

1-Aminocyclopropane-1-carboxylic acid hydrochloride

68781-13-5
142 suppliers
$33.00/5g

22059-21-8
423 suppliers
$14.00/1g

Yield:22059-21-8 84.1%

Reaction Conditions:

with triethylamine in 2-methyl-propan-1-ol;water; pH=6pH-value;Solvent;

Steps:

1 Example 1
To 1-aminocyclopropanecarboxylic acid hydrochloride (purity 98.7%, 2 g) were added water (2.7 g) and 2-methylpropan-1-ol (4.6 g).
Triethylamine (1.5 g) was added thereto to adjust the pH to 6.0, the obtained slurry was cooled to 20° C., and the precipitated crystals were collected by filtration.
The obtained crystals were washed with 2-methylpropan-1-ol (10.6 g), and dried under reduced pressure at 85° C. for 3 hr to give 1-aminocyclopropanecarboxylic acid non-hydrate (1.2 g, content: 99.5% (yield 84.1%), water content: 0.26%).

References:

SUMITOMO CHEMICAL COMPANY, LIMITED;KAWAMURA, Mitsunobu;OKAMOTO, Hiroaki US2020/95188, 2020, A1 Location in patent:Paragraph 0042

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6914-74-5 Synthesis

6914-74-5
70 suppliers
$48.00/1g

22059-21-8
423 suppliers
$14.00/1g

References

82998-00-3
2 suppliers
inquiry

22059-21-8
423 suppliers
$14.00/1g

References

1-(Cbz-amino)cyclopropanecarboxylic acid

84677-06-5
144 suppliers
$23.30/1G

22059-21-8
423 suppliers
$14.00/1g

References

99420-34-5
6 suppliers
inquiry

22059-21-8
423 suppliers
$14.00/1g

References

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