ChemicalBook CAS DataBase List Aminopyrine

Aminopyrine synthesis

7synthesis methods

Product Name:Aminopyrine
CAS Number:58-15-1
Molecular formula:C13H17N3O
Molecular Weight:231.29

Aminopyrine is synthesized from 4-Aminoantipyrine by catalytic hydrogenation (alkylation). Water is firstly added to the dissolving tank, heated to 50-60°C, put into 4-Aminoantipyrine under stirring, and poured into the hydrogenation tank after complete dissolving. Wash the dissolving tank with water, mix it with the nickel catalyst, and then add it to the hydrogenation tank. The hydrogenation tank was evacuated, then the vacuum valve was closed, hydrogen was introduced, and stirring was started. When the pressure rose to 0.245MPa, the hydrogen was stopped. Add formaldehyde and continue to feed hydrogen. The speed of adding formaldehyde is based on the standard of 1.8-2 cubic meters of hydrogen absorption per 5L of formaldehyde, and the reaction temperature is controlled at 60-85°C. After passing the test, filter by pressure, cool the filtrate to below 25°C, and separate out crystals, which are then filtered to obtain the crude aminopyrine. The crude aminopyrine, ethanol, and activated carbon were heated to 75-80°C, stirred for 1 hour, and filtered under pressure. The filtrate was cooled to 10°C, crystals were precipitated, filtered, washed with ethanol, and air-dried to obtain aminopyrine.

83-07-8 Synthesis

83-07-8
347 suppliers
$5.00/100mg

58-15-1
200 suppliers
$18.00/1g

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium acetate / 120 - 130 °C
2: 120 - 140 °C

References:

Hoechster Farbw. DE 144393, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 7,p. 634][Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 7,p. 634]

50-00-0 Synthesis