1-BENZYLOXY-4-BROMO-2-CHLOROBENZENE synthesis
- Product Name:1-BENZYLOXY-4-BROMO-2-CHLOROBENZENE
- CAS Number:56872-27-6
- Molecular formula:C13H10BrClO
- Molecular Weight:297.57
3964-56-5
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100-39-0
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56872-27-6
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Yield:56872-27-6 99%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 3 h;
Steps:
039.1
Step 1 Preparation of Compound 61 (0648) Benzyl bromide (1.57 mL, 13.3 mmol) and potassium carbonate (2.17 g, 15.7 mmol) were added to DMF solution (25 mL) of Compound 60 (2.50 g, 12.1 mmol), and the mixture was stirred at room temperature for 3 hours. Water was added to the mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate. The solvent was condensed under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate-hexane) to afford Compound 61 (3.56 g, yield 99%). (0649) 1H-NMR (CDCl3) δ: 7.52 (d, J=2.0 Hz, 1H), 7.45-7.25 (m, 6H), 6.83 (d, J=8.6 Hz, 1H), 5.14 (s, 2H). (0650) [M+H]=298, Method Condition 2: retention time 2.79 min
References:
US2015/246938,2015,A1 Location in patent:Paragraph 0648-0650
3964-56-5
240 suppliers
$5.00/5g
100-44-7
626 suppliers
$13.50/250G
56872-27-6
43 suppliers
$50.00/250mg
95-57-8
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$10.00/5g
56872-27-6
43 suppliers
$50.00/250mg