ChemicalBook CAS DataBase List 2-Chlorophenol

2-Chlorophenol synthesis

15synthesis methods

Product Name:2-Chlorophenol
CAS Number:95-57-8
Molecular formula:C6H5ClO
Molecular Weight:128.56

Preparation of 2-chlorophenol: 0.5 mole of tert-butyl hypochlorite is dropped, with stirring, into a solution or suspension of the 0.5 mole of phenol in 150-300 ml of carbon tetrachloride, the temperature being allowed to rise to the boiling point of the solvent. The mixture is then boiled under reflux for a further 2 hours, the carbon tetrachloride and the tert-butyl alcohol are distilled off, and the residue is fractionated collecting fraction boiling at 174.9 °C.
synthesis of 2-chlorophenol

3900-89-8 Synthesis

3900-89-8
376 suppliers
$6.00/1g

95-57-8
339 suppliers
$10.00/5g

Yield:95-57-8 99%

Reaction Conditions:

with dihydrogen peroxide in ethanol at 20; for 0.0166667 h;Green chemistry;Solvent;

Steps:

General procedure for the oxidation using H2O2

General procedure: A 25 ml flask was charged with phenylboronic acid (1 mmol). Then 1.6 mL H2O2 and 1 mL EtOH were added under stirring. The reaction was stirred for 1 min, then quenched by water (10 ml). The aqueous layer was extracted with 20 mL ethyl acetate for three times. The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The pure product was obtained without flash column chromatography and the purity was determine by TLC.

References:

Dong, Zhenhua;Liu, Mengmeng;Pan, Hongguo [Arkivoc,2021,vol. 2021,# 8]

17881-65-1 Synthesis

17881-65-1
16 suppliers
$60.00/100mg

95-57-8
339 suppliers
$10.00/5g

References

20788-42-5 Synthesis

20788-42-5
13 suppliers
$28.60/250mg

95-57-8
339 suppliers
$10.00/5g

References

Benzene, 1-chloro-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

126644-70-0
2 suppliers
inquiry

95-57-8
339 suppliers
$10.00/5g

References

615-41-8
238 suppliers
$5.00/1g

95-57-8
339 suppliers
$10.00/5g

References

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