1-Boc-4-(2-pyridyloxy)piperidine synthesis
- Product Name:1-Boc-4-(2-pyridyloxy)piperidine
- CAS Number:313490-35-6
- Molecular formula:C15H22N2O3
- Molecular Weight:278.35
109-04-6
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$6.00/25g
109384-19-2
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313490-35-6
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$60.00/100mg
Yield:313490-35-6 82%
Reaction Conditions:
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylatewith sodium hydride in 1-methyl-pyrrolidin-2-one at 20; for 0.166667 h;
Stage #2: 2-bromo-pyridine in 1-methyl-pyrrolidin-2-one; for 6 h;Heating / reflux;
Steps:
10
Preparation 10; tert-Butyl 4-(pyridin-2-yloxy)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine (3.0g, 14.9mmol) was added to a suspension of sodium hydride (60% in mineral oil, 600mg, 14.9mmol) in 1-methyl-2- pyrrolidinone (50mL) and the mixture was stirred at room temperature for 10 minutes. 2- Bromopyridine (1.43mL, 14.9mmol) was added and the mixture was heated under reflux for 6 hours. The mixture was then cooled to room temperature, diluted with ethyl acetate (250mL) and washed with brine (5x150mL). The organic solution was dried over magnesium sulfate and concentrated in vacuo. Purification of the residue by column chromatography on silica gel, eluting with pentane: ethyl acetate, 80: 20, afforded the title compound as a colourless oil in 82% yield, 3.40g.
References:
WO2005/105779,2005,A1 Location in patent:Page/Page column 38
142-08-5
513 suppliers
$6.00/5g
109384-19-2
471 suppliers
$5.00/1g
313490-35-6
27 suppliers
$60.00/100mg
109-09-1
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109384-19-2
471 suppliers
$5.00/1g
313490-35-6
27 suppliers
$60.00/100mg
142-08-5
513 suppliers
$6.00/5g
109384-19-2
471 suppliers
$5.00/1g
1972-28-7
395 suppliers
$15.00/5g
313490-35-6
27 suppliers
$60.00/100mg