ChemicalBook CAS DataBase List 1-Boc-hexahydro-1,4-diazepine

1-Boc-hexahydro-1,4-diazepine synthesis

5synthesis methods

Product Name:1-Boc-hexahydro-1,4-diazepine
CAS Number:112275-50-0
Molecular formula:C10H20N2O2
Molecular Weight:200.28

To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL) is added at room temperature. After 24 hours, water is added and the pH is adjusted to 10 using 10% NaOH. The aqueous phase is then extracted with dichloromethane (2 x 15 mL). The organic phase is dried and the solvent is evaporated to obtain tert-butyl 1,4-diazepane-1-carboxylate (1-Boc-hexahydro-1,4-diazepine) with a yield of 90.0%.

505-66-8 Synthesis

505-66-8
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24424-99-5 Synthesis

24424-99-5
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112275-50-0
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Yield:112275-50-0 90%

Reaction Conditions:

in acetic acid at 20; for 24 h;

Steps:

7 Example 7. Preparation of derivates of 1,4-diazepanes. tert-Butyl 1,4-diazepane-1-carboxylate.

To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL)at ambient temperature is added. After 24 hours, add water and adjust the pH to 10 with 10% NaOH. Extract the aqueous phase with dichloromethane (2 x 15 mL), dry the organic phase and eliminate the solvent, to obtain the compound tert-butyl 1,4-diazepane-1-carboxylate with 90.0% yield.; A liquid is obtained that was analyzed, obtaining the following data: IR ν_max (cm^-1): 2932, 2514, 1681, 1477, 1411, 1166, 991, 769 ( Figure 4 ).

References:

EP2578588,2013,A1 Location in patent:Paragraph 0110; 0111

505-66-8 Synthesis

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1070-19-5 Synthesis