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Important pharmaceutical intermediates Preparation Uses
Homopiperazine structure
Chemical Name:
HPRZ;Gao Paiqin;1,4-DIAZEPANE;hoMopiperazate;HOMOPIPERAZINE;High-piperazine;Homo-Piperazines;1,4-Diazepane 97%;AKOS BBS-00004278;Homopiperazine,98%
Molecular Formula:
Formula Weight:
MOL File:

Homopiperazine Properties

Melting point:
38-40 °C(lit.)
Boiling point:
169 °C(lit.)
refractive index 
1.4378 (estimate)
Flash point:
148 °F
Crystalline Mass
White to light yellow
Water Solubility 
Soluble in water.
Air Sensitive & Hygroscopic
CAS DataBase Reference
505-66-8(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
1H-1,4-Diazepine, hexahydro-(505-66-8)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,Xi
Risk Statements  21-34
Safety Statements  26-36/37/39-45-27
RIDADR  UN 3259 8/PG 2
WGK Germany  1
RTECS  HM3850000
Hazard Note  Irritant/Corrosive
HazardClass  8
PackingGroup  III
HS Code  29339900
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Homopiperazine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H16604 Homopiperazine 98% 505-66-8 25g $44.9 2018-11-13 Buy
TCI Chemical H0572 Homopiperazine >98.0%(GC)(T) 505-66-8 25g $52 2018-11-22 Buy
Alfa Aesar A15751 Homopiperazine, 98% 505-66-8 25g $89.3 2018-11-15 Buy
Alfa Aesar A15751 Homopiperazine, 98% 505-66-8 100g $253 2018-11-15 Buy
Alfa Aesar A15751 Homopiperazine, 98% 505-66-8 500g $578 2018-11-15 Buy

Homopiperazine Chemical Properties,Uses,Production

Important pharmaceutical intermediates

Homopiperazine is a nitrogen-containing seven-membered ring hetero-atomic compound and is an important pharmaceutical intermediate. The majority of its derivatives has strong biological activity and medicinal value and can be used for synthesizing homopiperazine hydrochloride, cyclizine, carbamazepine, chlorcyclizine and other drugs. Western medicine often takes homopiperazine as raw material for the modified quinoline and isoquinoline derivatives, quinolone derivative, thiazolidine carboxylic acid amide derivatives and other drugs, and for the synthesis of pyridazine, nitroxyl-containing benzylamine derivatives, water-soluble azole and other drugs which has good efficacy for the treatment of cardiovascular disease, interstitial plasma cell pneumonia especially for AIDS patients with Pneumocystis pneumonia, asthma, central nervous system disorders including depression and anxiety disorders. For example, 1-(5-isoquinoline-sulfonyl) homopiperazine hydrochloride is effective in the treatment of symptoms such as chronic angina disease, vitiligo, depression, anxiety, cerebral vasospasm and cerebral vasospasm caused cerebral ischemia and other symptoms.
Homopiperazine and its high-piperazine derivatives have become important pharmaceutical intermediates and have exhibited great potential of being sedative, anti-psychotic, anti-inflammatory and anti-neurotic and is an important product of a connecting link between the proceeding and the following in the chemical industry and pharmaceutical industry and have been widely applied to the pharmaceuticals, pesticides, surfactants, energetic materials and other fields.
Currently the domestic heterocyclic compounds are mainly used for producing the quinolone antibacterial drugs. This drug, through inhibiting the bacterial DNA gyrase, blocks the DNA replication and produces the antimicrobial effects. According to the report of ARMIGER H et al, after using homopiperazine as substitute of piperazine for the synthesis of drugs like cyclizine, homo-chlorcyclizine and other drugs, animal experiments had demonstrated that the activity of antihistamine drugs had been significantly enhanced. Its main products include quinoline and isoquinoline derivatives, quinolone derivative, thiazolidine carboxylic acid amide derivatives and other drugs, as well as the synthesis of disubstituted pyridazine, the nitroxyl-containing benzyl amine derivatives and water-soluble azole drug.
The derivative of homopiperazine molecule with the hydrogen atom in the amino group being substituted by long-chain alkyl or alkoxy can be used as wetting agents, emulsifying agents, detergents, coloring agents; homopiperazine and its derivatives, because of containing staining keratin filament, can be used as oxidation coloring agents and have vibrant colors and high solidness properties. It plays an important role in the dyeing, especially in the dyeing of human hair.
Polymers containing homopiperazine monomer have many unique properties such as being able to improve the melting point and improve their solubility. Resin and synthetic fiber containing such a polymer have been applied to a variety of special fields.
The above information is edited by the chemicalbook of Dai Xiongfeng.


Homopiperazine can be synthesized using amino compounds such as N-(2-cyanoethyl)-ethylenediamine, N-(β-hydroxy)-1,3-propanediamine, ethylenediamine as raw material so that homopiperazine has various kinds of synthetic routes according to different raw materials.
With the development of China's petrochemical industry, for the synthesis of the starting raw material of homopiperazine, alcohols and ethylene diamine, it not only has low price but also can get high-quality product as well as extremely abundant source. Currently, though there are homopiperazine domestic manufacturers, but the technology is lagged behind, the quality is not high and the production output is limited, all the above points are in urgent need for being transformed and improved. From this perspective, it is imperative for accelerating the process of development of fine chemical products of homopiperazine with a wide range of application. Therefore, the market prospect of the homopiperazine is very broad.
Using ethylenediamine as the raw material: the method uses the easily available ethylenediamine as the initial raw material, further goes through sulfonylation, cyclization, de-sulfonylation, 3-step reaction for synthesizing homopiperazine with the total yield being 78%. Within this synthetic method, during the first step of ethylenediamine sulfonylation, the addition of a phase transfer catalyst can significantly improve the product yield with the yield being 86%. During the second step of cyclization reaction, selection of NaH/ DMF reaction system can enable the completion of the cyclization reaction under milder reaction conditions. Finally, under HBr/HAc/PhOH reaction conditions, remove the sulfonyl group with a yield being 91% to give the final product homopiperazine. The results indicate that it is an excellent homopiperazine synthesis route of various kinds of advantages including easily available raw materials, simple operation and high yield with certain prospects for industrial application.


It can be used as organic and pharmaceutical synthesis intermediates, for example, being applied to the synthesis of fasudil hydrochloride.
Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer disease.

Chemical Properties

white to light yellow crystalline mass


pharmaceutical intermediate

Homopiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

Homopiperazine Suppliers

Global( 272)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32606 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
0086-13720134139 CHINA 956 58
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871
+86 519 86305879 CHINA 3112 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20177 58
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 940 58
career henan chemical co
+86-371-86658258 CHINA 19975 58

View Lastest Price from Homopiperazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-03 Homopiperazine in stock Factory
US $1.00 / KG 1KG TOP 3 Factory in China Top 3 largest production capacity Factory Chemwill Asia Co.,Ltd.
2018-08-09 Homopiperazine
US $1.00 / KG 1KG 99% Customized career henan chemical co

Homopiperazine Spectrum

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