1-chloro-2-[(E)-2-nitroethenyl]benzene synthesis
- Product Name:1-chloro-2-[(E)-2-nitroethenyl]benzene
- CAS Number:22568-07-6
- Molecular formula:C8H6ClNO2
- Molecular Weight:183.59
75-52-5
89-98-5
22568-07-6
GENERAL METHOD: Hexylamine (20 mg, 0.2 mmol) was added to a solution of toluene (4 mL) containing 3a (212 mg, 2.0 mmol), silica gel (200 mg) and nitromethane (134 mg, 2.2 mmol). The reaction mixture was stirred at 90 °C for 4 hours. After completion of the reaction, the silica gel was removed by filtration and the filter cake was washed with toluene. The filtrate was concentrated under reduced pressure at 40 °C to give the crude product. The crude product was purified by silica gel column chromatography using heptane-acetone (5:1, v/v) as eluent to afford the target compound 5a (268 mg, 90% yield).
Yield:22568-07-6 93%
Reaction Conditions:
with (S)-4-amino-2-(((benzyloxy)carbonyl)amino)butanoic acid in ethanol at 30; for 48 h;Henry Nitro Aldol Condensation;Time;Reagent/catalyst;Solvent;
References:
Karadeniz, Leman;Astley, Stephen T. [Research on Chemical Intermediates,2013,vol. 39,# 7,p. 3407 - 3415]
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