1-chloroethyl pivalate synthesis

6synthesis methods

Product Name:1-chloroethyl pivalate
CAS Number:40258-80-8
Molecular formula:C7H13ClO2
Molecular Weight:164.63

75-07-0 Synthesis

75-07-0
410 suppliers
$14.00/5mL

630-19-3 Synthesis

630-19-3
300 suppliers
$13.00/1g

40258-80-8
7 suppliers
inquiry

Yield:40258-80-8 88%

Reaction Conditions:

with zinc(II) chloride at 50; for 16 h;

Steps:

12.a

To a mixture of acetaldehyde (0.84 mL, 16.6 mmol) in zinc chloride (62 mg, 0.45 mmol) was added dropwise 2,2-dimethyl-propionaldehyde (2.05 mL, 16.6 mmol). The mixture was then heated to 50° C. for 16 h. The blackish material was filtered through a plug of silica gel with dichloromethane to afford 2,2-dimethyl-propionic acid 1-chloro-ethyl ester as an oil (2.4 g, 88%) after the removal of dichloromethane under reduced pressure: ¹H NMR (300 MHz, CDCl₃): δ 6.64-6.59 (m, 1H), 1.82 (d, J=6.7 Hz, 3H), 1.36 (s, 9H).

References:

US2009/28925,2009,A1 Location in patent:Page/Page column 117