1-Methyl-1H-pyrazole-4-boronic acid synthesis
- Product Name:1-Methyl-1H-pyrazole-4-boronic acid
- CAS Number:847818-55-7
- Molecular formula:C4H7BN2O2
- Molecular Weight:125.92
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Yield:-
Reaction Conditions:
with tetrakis(triphenylphosphine)platinum;sodium acetate in 1,4-dioxaneReflux;
Steps:
Step 2.
Add 1,4-dioxane (20mL), 4-bromo-1-methyl-1H-pyrazole (0.33g, 2mmol), diboronic acid pinacol ester (0.78 g, 3mmol), anhydrous sodium acetate (0.58g, 5.2mmol), Pt[P(C6H5)3]4(0.036g, 0.03mmol), reflux with stirring, and purify it on a silica gel column to obtain a solid product after passing through. Hydrolysis and recrystallization give 4-boronic acid-1-methyl-1H-pyrazole.
References:
CN112724134, 2021, A Location in patent:Paragraph 0153; 0156
15803-02-8
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$5.00/1g
847818-55-7
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$21.21/1gm:
930-36-9
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847818-55-7
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847818-55-7
160 suppliers
$21.21/1gm: