ChemicalBook CAS DataBase List Pyraclostrobin

Pyraclostrobin synthesis

7synthesis methods

Product Name:Pyraclostrobin
CAS Number:175013-18-0
Molecular formula:C19H18ClN3O4
Molecular Weight:387.82

Production involves a multi-step synthesis starting with p-chlorophenylhydrazine hydrochloride and ortho-nitrotoluene as key raw materials. The process includes sequential reactions such as synthesis, cyclization, oxidation, bromination, etherification, reduction, esterification, and methylation to build the final strobilurin structure. One efficient method uses methyl [2-(bromomethyl)phenyl]methoxycarbamate and 1-(4-chlorophenyl)-3-hydroxy-1H-pyrazole in the presence of potassium carbonate and acetone under reflux conditions for several hours. After filtration, drying, and crystallization, the final product is obtained with high purity and yield, making the process suitable for industrial-scale production.

151827-83-7 Synthesis

Methyl [2-(bromomethyl)phenyl]methoxycarbamate

151827-83-7
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76205-19-1 Synthesis

1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE

76205-19-1
202 suppliers
$7.00/5g

175013-18-0
305 suppliers
$50.00/100mg

Yield:175013-18-0 83%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide;propan-2-one; for 7 h;Reflux;

Steps:

2.5 Example 2

(5) Dissolving methyl N-methoxy-N- (2-bromomethylphenyl) carbamate with DMF as solvent0.12 mol of 1- (4-chlorophenyl) -pyrazolol, 0.15 mol of K2CO3 and acetone were placed in a reactor. After the temperature was raised to reflux, a solution of 0.1 mol of N-methoxy-N-2-bromomethylphenylcarbamate solution was refluxed for 7 hours. After filtration and drying, the solid material was completely dissolved by stirring with anhydrous methanol, and then cooled and crystallized to obtain a light The yellow solid is the target product pyraclostrobin.
The purity of the product pyraclostrobin prepared by the above method was 89.1% and the yield was 83%

References:

CN106008347,2016,A Location in patent:Paragraph 0027; 0033; 0034

76205-19-1 Synthesis

76205-19-1
202 suppliers
$7.00/5g

Carbamic acid, N-[2-(chloromethyl)phenyl]-N-methoxy-, methyl ester

1334322-60-9
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175013-18-0
305 suppliers
$50.00/100mg

References

106-39-8 Synthesis

106-39-8
484 suppliers
$14.00/5g

Carbamic acid, N-methoxy-N-[2-[(1H-pyrazol-3-yloxy)methyl]phenyl]-, methyl ester

175013-17-9
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175013-18-0
305 suppliers
$50.00/100mg

References

3958-60-9 Synthesis

3958-60-9
259 suppliers
$8.00/1g

175013-18-0
305 suppliers
$50.00/100mg

References

55581-63-0
5 suppliers
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175013-18-0
305 suppliers
$50.00/100mg

References

Pyraclostrobin Related Search:

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