1H-BenziMidazole-1-carboxylicacid,5-(broMoMethyl)-,1,1-diMethylethylester synthesis
- Product Name:1H-BenziMidazole-1-carboxylicacid,5-(broMoMethyl)-,1,1-diMethylethylester
- CAS Number:1037207-08-1
- Molecular formula:C13H15BrN2O2
- Molecular Weight:311.17
Yield:1037207-08-1 89%
Reaction Conditions:
with N-Bromosuccinimide in tetrachloromethane at 90;
Steps:
tert-butyl 5-(bromomethyl)-i H-i ,3-benzodiazole-i -carboxylate.
tert-butyl 5-methyl-i H1 ,3-benzodiazole-1 -carboxylate (0.8 g, 3.44 mmol), N-bromosuccimide (0.64g, 3.62 mmol), dibenzoyl peroxide (22 mg, 0.1 mmol) were suspended in tetrachloromethane (16 ml), Reaction mixture was stirred overnight at 90°C. After that time reaction mixture was cooled to0 °C, precipitate was filtered off and filtrate was concentrated in vacuo to give desired product as pale yellow oil. (0.95 g, 89%). UPLC (254nm): RT=3.75 mm, 80% purity, [M+H]=31 2.75.
References:
WO2018/178384,2018,A1 Location in patent:Page/Page column 190
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