5-Methylbenzimidazole synthesis
- Product Name:5-Methylbenzimidazole
- CAS Number:614-97-1
- Molecular formula:C8H8N2
- Molecular Weight:132.16
Yield: 95%
Reaction Conditions:
with [PVP-SO3H] HSO4 at 60; for 0.75 h;
Steps:
General procedure for the preparation of benzimidazole, benzoxazole, andbenzothiazole derivatives
General procedure: o-Phenylenediamine, o-aminophenol or o-aminothiophenol (1 mmol), ortho esters(1.5 mmol) and [PVP-SO3H] HSO4 (7 mg, 4 mol %) were mixed and the resulting mixturewas stirred at 60 C for the appropriate time (Table 2). After completion of thereaction, as indicated by TLC (EtOAc:n-hexane; 1:3), ethyl acetate (10 mL) was addedand the catalyst was separated by filtration. The organic phase was washed with water,and then the organic phase was dried by Na2SO4. After filtration of the drying agent,ethyl acetate was removed under reduced pressure to get the desired product. The spectraldata of representative compounds follow.
References:
Roudsari, Fatemeh Pakpour;Seddighi, Mohadeseh;Shirini, Farhad;Tajik, Hassan [Organic Preparations and Procedures International,2020,p. 1 - 14]
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